{"doi":"10.1002/jmri.70056","title":"Comparison of Magnetic Resonance Spectra Acquired With Hybrid <scp>PET</scp> / <scp>MR</scp> and Standalone <scp>MR</scp> Scanners","abstract":"BACKGROUND: The effect of the positron emission tomography (PET) modality in hybrid PET/MR scanners on MR spectral quality is unclear. PURPOSE: To evaluate spectral quality, quantification, and repeatability of brain MR spectroscopy (MRS) acquired on PET/MR and standalone MR scanners. STUDY TYPE: Prospective. SUBJECTS: 23 healthy adults (male/female = 11/12, age = 27 ± 11 years). FIELD STRENGTH/SEQUENCE: 3T, semi-localized by adiabatic selective refocusing. ASSESSMENT: Single voxel MR spectra were acquired with GE Signa PET/MR and Siemens Prisma Fit MR scanners in healthy volunteers, and additionally with a GE Premier MR scanner in vitro. Spectral quality, metabolite concentrations, and repeatability were evaluated. STATISTICAL TESTS: Linear mixed models assessed signal-to-noise ratio (SNR), full width at half maximum (FWHM), and metabolites/total creatine (tCr). Intraclass correlation coefficients (ICCs) determined repeatability; mean squared error (MSE) evaluated accuracy of quantification. Values are reported as mean ± standard deviation. Significance was determined by p ≤ 0.05. RESULTS: In vivo spectra acquired using the Siemens standalone MR showed significantly higher SNR (PET/MR: 118.8 ± 19.1, MR: 132.2 ± 24.4) but significantly broader FWHM (PET/MR: 7.2 ± 1.8 Hz, MR: 8.4 ± 2.5 Hz) compared to PET/MR. All metabolite ratios were significantly higher in spectra acquired on the standalone MR. Within-session repeatability was good (ICC > 0.75), and between-session repeatability was moderate to excellent (ICC 0.5 to > 0.90) for all metabolites in vivo. In vitro spectra acquired with the PET/MR had significantly higher SNR (329.1 ± 46.1) than the Siemens standalone MR (150.8 ± 49.3) but significantly lower than the GE standalone MR (395.9 ± 33.7). The PET/MR produced narrower FWHM (2.1 ± 0.4 Hz) than the Siemens standalone MR (4.1 ± 1.7 Hz) but broader than the GE standalone MR (1.6 ± 0.1 Hz) and lower MSE for some metabolites. DATA CONCLUSION: MR spectral quality appears uncompromised when acquired with hybrid PET/MR compared to standalone MR.","journal":"Journal of Magnetic Resonance Imaging","year":2025,"id":571671,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10062,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5219,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1242241,"name":"Aditya Bhattacharya","orcid":"0009-0003-5300-6799","position":1,"is_corresponding":false},{"id":328795,"name":"Benjamin B. Risk","orcid":"0000-0003-1090-0777","position":2,"is_corresponding":false},{"id":1070746,"name":"Taylor M. Zuleger","orcid":"0000-0002-4622-4005","position":3,"is_corresponding":false},{"id":406891,"name":"Sagar Mandava","orcid":"0000-0003-3425-7579","position":4,"is_corresponding":false},{"id":459002,"name":"Ralph Noeske","orcid":"0000-0002-6193-366X","position":5,"is_corresponding":false},{"id":487068,"name":"Candace C. Fleischer","orcid":"0000-0003-3265-2276","position":6,"is_corresponding":false},{"id":203449,"name":"C. MacDonald","orcid":null,"position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T02:57:19.669553Z","pmid":"40758419","pmcid":"PMC12604544","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}