{"doi":"10.1002/jmri.29825","title":"Repeatability of Magnetic Resonance Elastography‐Derived Mechanical Parameters in Intracranial Meningiomas","abstract":"BACKGROUND: Magnetic resonance elastography (MRE) quantifies tissue viscoelasticity, offering insights into intracranial meningiomas. MRE-derived parameters, including the storage modulus (G') and the magnitude of the complex modulus (|G*|), may aid neurosurgical planning, but their repeatability remains unexplored in brain tumors. PURPOSE/HYPOTHESIS: To evaluate the repeatability of G' and |G*| in meningiomas, the influence of tumor volume and spatial location on variability, and ranking stability across paired elastograms. STUDY TYPE: Prospective. POPULATION/SUBJECTS: Seventeen paired MRE scans from 16 patients with meningiomas (mean age 64 ± 12 years, 10 females) scheduled for resection. FIELD STRENGTH/SEQUENCE: MRE was performed on a 3 T system using a single-shot spin-echo echo-planar imaging (SE-EPI) sequence. ASSESSMENT: Tumors were segmented on contrast-enhanced T1-weighted images; distance and volume metrics were extracted. Regions of interest were applied to G' and |G*| elastograms. Repeatability was evaluated using the coefficient of variation (CV%). Ranking stability was assessed by comparing median G' or |G*| values. STATISTICAL TESTS: The difference in CV% was assessed using the Wilcoxon signed rank test. Linear regression assessed the effect of tumor volume and distance from the external occipital protuberance (EOP) on CV%. The Wilcoxon signed-rank test evaluated ranking stability and scan-rescan CV%. Statistical significance was defined as p < 0.05. RESULTS: The difference in CV% G' (14.89 ± 12.32) and CV% |G*| (13.88 ± 12.60) was not significant (p = 0.61). Tumor volume inversely correlated with CV% (G': β = -0.75 |G*|: β = -0.59). Tumor-EOP distance had no significant effect (G': p = 0.58, |G*|: p = 0.23). Rankings remained stable (G': p = 0.82, |G*|: p = 0.71). DATA CONCLUSION: MRE-derived parameters are repeatable in intracranial meningiomas, with G' and |G*| being equally stable. Larger tumors yielded more consistent estimates. Preserved ranking stability supports the use of MRE in preoperative planning. EVIDENCE LEVEL: 2. TECHNICAL EFFICACY: Stage 2.","journal":"Journal of Magnetic Resonance Imaging","year":2025,"id":521195,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1391524,"name":"Ancuta Ioana Friismose","orcid":"0000-0003-3248-230X","position":1,"is_corresponding":false},{"id":1391525,"name":"Bo Halle","orcid":"0000-0001-9930-4490","position":2,"is_corresponding":false},{"id":1391526,"name":"Christian Bonde Pedersen","orcid":"0000-0003-3761-0446","position":3,"is_corresponding":false},{"id":1391527,"name":"Bo Redder Mussmann","orcid":"0000-0003-2119-5129","position":4,"is_corresponding":false},{"id":1136741,"name":"Emi Hojo","orcid":"0000-0002-4229-0435","position":5,"is_corresponding":false},{"id":675121,"name":"Ziying Yin","orcid":"0000-0003-3235-966X","position":6,"is_corresponding":false},{"id":1391528,"name":"Mathias Just Nortvig","orcid":"0009-0004-1562-5115","position":7,"is_corresponding":false},{"id":1392054,"name":"Kerstin Lagerstrand","orcid":null,"position":8,"is_corresponding":false},{"id":1391529,"name":"Frantz Rom Poulsen","orcid":"0000-0001-5715-6901","position":9,"is_corresponding":false},{"id":1391523,"name":"Jan Saip Aunan‐Diop","orcid":"0000-0002-3009-6344","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T02:49:44.558743Z","pmid":"40372143","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}