{"doi":"10.1002/jmri.29605","title":"Same‐Day Repeatability and 28‐Day Reproducibility of Xenon <scp>MRI</scp> Ventilation in Children With Cystic Fibrosis in a Multi‐Site Trial","abstract":"BACKGROUND: MRI with xenon-129 gas (Xe MRI) can assess airflow obstruction and heterogeneity in lung diseases. Specifically, Xe MRI may represent a sensitive modality for future therapeutic trials of cystic fibrosis (CF) therapies. The reproducibility of Xe MRI has not yet been assessed in the context of a multi-site study. PURPOSE: To determine the same-day repeatability and 28-day reproducibility of Xe MRI in children with CF. STUDY TYPE: Four-center prospective, longitudinal. POPULATION: ) ≥85% predicted). FIELD STRENGTH/SEQUENCE: 3-T, two-dimensional (2D) gradient-echo (GRE) sequence. ASSESSMENT: ) were performed. To assess same-day reproducibility, Xe MRI was performed twice within the first visit, and procedures were repeated at 28 days. Xe hypoventilation was quantified using ventilation-defect percentage (VDP) and reader-defect volume (RDV). For VDP, hypoventilated voxels from segmented images were identified using a threshold of <60% mean whole-lung signal and expressed as a percentage of the lung volume. For RDV, hypoventilation was identified by two trained readers and expressed as a percentage. STATISTICAL TESTS: Inter-site comparisons were conducted using Kruskal-Wallis nonparametric tests with Dunn's multiple-comparisons tests. Differences for individuals were assessed using Wilcoxon matched-pairs tests. Bland-Altman tests were used to evaluate same-day repeatability, 28-day reproducibility, and inter-reader agreement. A P-value ≤0.05 was considered significant. RESULTS: was 6.6 (6.3-7.4). Xe MRI had high same-day reproducibility (mean VDP difference 0.12%, 95% limits of agreement [-3.2, 3.4]; mean RDV difference 0.42% [-2.5, 3.3]). At 28 days, 26/31 participants (84%) fell within the same-day 95% limits of agreement. DATA CONCLUSION: Xe MRI may offer excellent same-day and short-term reproducibility. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.","journal":"Journal of Magnetic Resonance Imaging","year":2024,"id":426614,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9625,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":401846,"name":"David J. Roach","orcid":"0000-0001-5199-0452","position":1,"is_corresponding":false},{"id":489815,"name":"Joseph W. Plummer","orcid":"0000-0002-0200-7869","position":2,"is_corresponding":false},{"id":319689,"name":"Matthew M. Willmering","orcid":"0000-0002-4356-9622","position":3,"is_corresponding":false},{"id":1127878,"name":"Brandon Zanette","orcid":"0000-0001-5645-0180","position":4,"is_corresponding":false},{"id":1127879,"name":"Giles Santyr","orcid":"0000-0001-7396-188X","position":5,"is_corresponding":false},{"id":347635,"name":"Sean B. Fain","orcid":"0000-0001-5461-0646","position":6,"is_corresponding":false},{"id":423711,"name":"Michael J. Rock","orcid":"0000-0001-9665-1737","position":7,"is_corresponding":false},{"id":474493,"name":"Jaime F. Mata","orcid":"0000-0002-2274-1470","position":8,"is_corresponding":false},{"id":720960,"name":"Deborah Froh","orcid":"0000-0002-0685-2680","position":9,"is_corresponding":false},{"id":487097,"name":"Sanja Stanojevic","orcid":"0000-0001-7931-8051","position":10,"is_corresponding":false},{"id":401847,"name":"Zackary I. Cleveland","orcid":"0000-0001-6195-9061","position":11,"is_corresponding":false},{"id":337408,"name":"Félix Ratjen","orcid":"0000-0003-4057-6592","position":12,"is_corresponding":false},{"id":319693,"name":"Jason C. Woods","orcid":"0000-0002-8080-7511","position":13,"is_corresponding":false},{"id":319687,"name":"Laura L. Walkup","orcid":"0000-0002-5060-6401","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T01:58:42.796720Z","pmid":"39257323","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}