{"doi":"10.1002/jmri.27383","title":"Multishot Diffusion‐Weighted <scp>MRI</scp> of the Breast With Multiplexed Sensitivity Encoding (<scp>MUSE</scp>) and Shot Locally <scp>Low‐Rank</scp> (S<scp>hot‐LLR</scp>) Reconstructions","abstract":"BACKGROUND: Diffusion-weighted imaging (DWI) has shown promise to screen for breast cancer without a contrast injection, but image distortion and low spatial resolution limit standard single-shot DWI. Multishot DWI methods address these limitations but introduce shot-to-shot phase variations requiring correction during reconstruction. PURPOSE: To investigate the performance of two multishot DWI reconstruction methods, multiplexed sensitivity encoding (MUSE) and shot locally low-rank (shot-LLR), compared to single-shot DWI in the breast. STUDY TYPE: Prospective. POPULATION: A total of 45 women who consented to have multishot DWI added to a clinically indicated breast MRI. FIELD STRENGTH/SEQUENCES: -weighted imaging, and contrast-enhanced MRI at 3T. ASSESSMENT: Three blinded observers scored images for 1) general image quality (perceived signal-to-noise ratio [SNR], ghosting, distortion), 2) lesion features (discernment and morphology), and 3) perceived resolution. Apparent diffusion coefficient (ADC) of the lesion was also measured and compared between methods. STATISTICAL TESTS: Image quality features and perceived resolution were assessed with a mixed-effects logistic regression. Agreement among observers was estimated with a Krippendorf's alpha using linear weighting. Lesion feature ratings were visualized using histograms, and correlation coefficients of lesion ADC between different methods were calculated. RESULTS: MUSE and shot-LLR images were rated to have significantly better perceived resolution (P < 0.001), higher SNR (P < 0.005), and a lower level of distortion (P < 0.05) with respect to single-shot DWI. Shot-LLR showed reduced ghosting artifacts with respect to both MUSE (P < 0.001) and single-shot DWI (P < 0.001). Eight-shot DWI had improved perceived SNR and perceived resolution with respect to four-shot DWI (P < 0.005). DATA CONCLUSION: Multishot DWI enables increased resolution and improved image quality with respect to single-shot DWI in the breast. Shot-LLR reconstructs multishot DWI with minimal ghosting artifacts. The improvement of multishot DWI in image quality increases with an increased number of shots. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY STAGE: 2.","journal":"Journal of Magnetic Resonance Imaging","year":2020,"id":98741,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":486716,"name":"Debra M. Ikeda","orcid":"0000-0002-8663-8448","position":1,"is_corresponding":false},{"id":486717,"name":"Sarah M Pittman","orcid":"0009-0003-7104-3761","position":2,"is_corresponding":false},{"id":487636,"name":"Dilan Samarawickrama","orcid":null,"position":3,"is_corresponding":false},{"id":409600,"name":"Arnaud Guidon","orcid":"0000-0001-6777-1633","position":4,"is_corresponding":false},{"id":304556,"name":"Jarrett Rosenberg","orcid":"0000-0003-2706-3290","position":5,"is_corresponding":false},{"id":486718,"name":"Shu-Tian Chen","orcid":"0000-0003-2650-3338","position":6,"is_corresponding":false},{"id":486719,"name":"Satoko Okamoto","orcid":"0000-0001-6042-8269","position":7,"is_corresponding":false},{"id":461270,"name":"Bruce L. Daniel","orcid":"0000-0003-0475-5892","position":8,"is_corresponding":false},{"id":301562,"name":"Brian A. Hargreaves","orcid":"0000-0003-0982-3508","position":9,"is_corresponding":false},{"id":461269,"name":"Catherine J. Moran","orcid":"0000-0001-9748-9495","position":10,"is_corresponding":false},{"id":263267,"name":"Yuxin Hu","orcid":"0000-0001-8045-9978","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T22:36:58.511143Z","pmid":"33067849","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}