{"doi":"10.1002/jmor.1050580110","title":"Further studies in modified mitosis","abstract":"<jats:title>Abstract</jats:title><jats:p>In a paper published by the author in 1931 there was described a process of cell division called ‘modified mitosis.’ The present report adds quantitative studies of the process and a general evaluation of it and its role in the development of the embryo. Cell counts were made in various stages of chick embryos and the mitotic indices determined. In no cases can these mitotic indices account for the growth which the cell counts indicate. Periodicity in cell division in the chick cannot be established. Modified mitosis appears after careful study to be fundamentally mitotic in nature. Actual division of chromatin, nucleus, and cytoplasm occurs. Modified mitosis is not amitotic in character, but it is probable that it is what has been reported in the past as amitosis. It is very doubtful whether amitosis is found in the chick or in any of the vertebrates. Modified mitosis is part of the active phase of cell division and cannot be explained away as merely resting stages containing one or two nucleoli. It is probable that the division of chromatin nucleoli cannot be accounted for on any other basis than that of modified mitosis. In modified mitosis we undoubtedly see irreversible cell differentiation. The genetic implications of this process are not yet clear. If present interpretations of modified mitosis are in error a complete revision of our ideas of typical mitosis is in order.</jats:p>","journal":"Journal of Morphology","year":1935,"id":42525,"datarank":2.337215777193178,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":1.866891644803805,"self_endowment_contribution":0.47032413238937254,"citer_contribution":1.866891644803805,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":22,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":203424,"name":"Howard Brown Stough","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18998881","pmcid":null,"openalex_id":"https://openalex.org/W2050894103","authors":[],"funders":[],"total_grants":0,"fwci":5.5396,"citation_percentile":0.95167785,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjmor.1050580110","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmor.1050580110","host_type":"publisher"},{"url":"https://doi.org/10.1002/jmor.1050580110","host_type":"journal"}],"fields_of_study":["Microtubule and mitosis dynamics","Genomic variations and chromosomal abnormalities","Cancer Genomics and Diagnostics","Biology"],"mesh_terms":[],"keywords":["Mitosis","Biology","Cell division","Chromatin","Nucleolus","Cell biology","Interphase","Cytoplasm","Cell cycle","Cell","Genetics","DNA"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-14T03:31:57.293754Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}