{"doi":"10.1002/jlcr.855","title":"Synthesis of [1‐<sup>11</sup>C]ethyl iodide from [<sup>11</sup>C]carbon monoxide and its application in alkylation reactions","abstract":"<jats:title>Abstract</jats:title><jats:p>A method is presented for preparing [1‐<jats:sup>11</jats:sup>C]ethyl iodide from [<jats:sup>11</jats:sup>C]carbon monoxide. The method utilizes methyl iodide and [<jats:sup>11</jats:sup>C]carbon monoxide in a palladium‐mediated carbonylation reaction to form a mixture of [1‐<jats:sup>11</jats:sup>C]acetic acid and [1‐<jats:sup>11</jats:sup>C]methyl acetate. The acetates are reduced to [1‐<jats:sup>11</jats:sup>C]ethanol and subsequently converted to [1‐<jats:sup>11</jats:sup>C]ethyl iodide. The synthesis time was 20 min and the decay‐corrected radiochemical yield of [1‐<jats:sup>11</jats:sup>C]ethyl iodide was 55 ± 5%. The position of the label was confirmed by <jats:sup>13</jats:sup>C‐labelling and <jats:sup>13</jats:sup>C‐NMR analysis. [1‐<jats:sup>11</jats:sup>C]Ethyl iodide was used in two model reactions, an <jats:italic>O</jats:italic>‐alkylation and an <jats:italic>N</jats:italic>‐alkylation. Starting with approximately 2.5 GBq of [<jats:sup>11</jats:sup>C]carbon monoxide, the isolated decay‐corrected radiochemical yields for the ester and the amine derivatives were 45 ± 0.5% and 25 ± 2%, respectively, based on [<jats:sup>11</jats:sup>C]carbon monoxide. Starting with 10 GBq of [<jats:sup>11</jats:sup>C]carbon monoxide, 0.55 GBq of the labelled ester was isolated within 40 min with a specific radioactivity of 36 GBq/µmol. Copyright © 2004 John Wiley &amp; Sons, Ltd.</jats:p>","journal":"Journal of Labelled Compounds and Radiopharmaceuticals","year":2004,"id":32198,"datarank":0.799717448683379,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.39350991851804745,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.39350991851804745,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":9,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":170921,"name":"Gunnar Antoni","orcid":null,"position":1,"is_corresponding":false},{"id":170923,"name":"Bengt Långström","orcid":null,"position":2,"is_corresponding":false},{"id":170919,"name":"Jonas Eriksson","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24523987","pmcid":null,"openalex_id":"https://openalex.org/W1965175875","authors":[],"funders":[],"total_grants":0,"fwci":1.9549,"citation_percentile":0.84696348,"influential_citations":0,"citation_trend":[{"year":2015,"count":2},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2023,"count":1}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jlcr.855","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jlcr.855","host_type":"BRONZE"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jlcr.855","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjlcr.855","host_type":"publisher"},{"url":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/jlcr.855","host_type":"publisher"},{"url":"https://doi.org/10.1002/jlcr.855","host_type":"journal"}],"fields_of_study":["Medical Imaging Techniques and Applications","Chemical Reactions and Isotopes","Glioma Diagnosis and Treatment","Chemistry"],"mesh_terms":[],"keywords":["Chemistry","Ethyl iodide","Carbon monoxide","Methyl iodide","Iodide","Carbonylation","Alkylation","Acetic acid","Ethyl acetate","Monoxide","Nuclear chemistry","Medicinal chemistry","Organic chemistry","Catalysis"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T10:50:02.587630Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}