{"doi":"10.1002/jlcr.4071","title":"A simplified protocol for the automated production of 2‐[<sup>18</sup>F]fluoro‐3‐[2‐((S)‐3‐pyrrolinyl)methoxy]pyridine ([<sup>18</sup>F]nifene) on an IBA Synthera® module","abstract":"The α4β2 nicotinic acetylcholine receptor (nAChR) ligand 2‐[ 18 F]fluoro‐3‐[2‐((S)‐3‐pyrrolinyl)methoxy]pyridine ([ 18 F]nifene) has been synthesized in 10% decay‐corrected radiochemical yield using the IBA Synthera® platform (IBA Cyclotron Solutions, Louvain‐la‐Neuve, Belgium) with an integrated fluidic processor (IFP). Boc‐nitronifene served as the precursor, and 20% trifluoroacetic acid (TFA) was used to deprotect the Boc‐group after radiolabeling. By omitting the solvent extraction step after radiolabeling, the process was simplified to a single step with no manual intervention. [ 18 F]Nifene was obtained in decay‐corrected radiochemical yields of 10 ± 2% ( n = 20) and radiochemical purity &gt;99%. Typical specific radioactivities of 2700–4865 mCi/μmole (100–180 GBq/μmol) were measured at the end of synthesis; total synthesis times were about 1 h 40 min.","journal":"Journal of Labelled Compounds and Radiopharmaceuticals","year":2023,"id":379213,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1035928,"name":"Jeffrey S. Souris","orcid":"0000-0002-9591-9313","position":1,"is_corresponding":false},{"id":739013,"name":"Anna Kucharski","orcid":null,"position":2,"is_corresponding":false},{"id":363035,"name":"R. Freifelder","orcid":null,"position":3,"is_corresponding":false},{"id":579729,"name":"Jogeshwar Mukherjee","orcid":"0000-0003-1009-877X","position":4,"is_corresponding":false},{"id":361956,"name":"Chin‐Tu Chen","orcid":"0000-0003-2508-8726","position":5,"is_corresponding":false},{"id":361955,"name":"Mohammed Bhuiyan","orcid":"0000-0003-1116-0280","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T01:16:52.622552Z","pmid":"37927198","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}