{"doi":"10.1002/jlb.36.6.771","title":"Inhibition of Yeast Phagocytosis in Macrophage Cultures Treated With Slime Polysaccharide Purified From Pseudomonas aeruginosa","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>This study was initiated to determine whether purified slime polysacchar- ide(PSP) from P aeruginosa inhibits the ingestion of heat killed Saccharomyces cerevisiae particles in macrophage cultures. Relative to controls, direct phagocytosis assays revealed that the percentages of phagocytes and the numbers of ingested yeast particles per phagocyte decreased in a dose-dependent manner in PSP-treated cultures. Thus, PSP may act as a virulence factor in vivo by impairing the phagocytic capacity of macrophages.</jats:p>","journal":"Journal of Leukocyte Biology","year":1984,"id":687723,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1796622,"name":"Rama Ganguly","orcid":null,"position":1,"is_corresponding":false},{"id":1796623,"name":"John F Breen","orcid":null,"position":2,"is_corresponding":false},{"id":1796621,"name":"Robert J Grasso","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Inhibition of Yeast Phagocytosis in Macrophage Cultures Treated With Slime Polysaccharide Purified From Pseudomonas aeruginosa","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>This study was initiated to determine whether purified slime polysacchar- ide(PSP) from P aeruginosa inhibits the ingestion of heat killed Saccharomyces cerevisiae particles in macrophage cultures. Relative to controls, direct phagocytosis assays revealed that the percentages of phagocytes and the numbers of ingested yeast particles per phagocyte decreased in a dose-dependent manner in PSP-treated cultures. Thus, PSP may act as a virulence factor in vivo by impairing the phagocytic capacity of macrophages.</jats:p>","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6438263","pmcid":null,"openalex_id":"https://openalex.org/W2187766237","authors":[],"funders":[],"total_grants":0,"fwci":0.3472,"citation_percentile":0.59731281,"influential_citations":0,"citation_trend":[{"year":2015,"count":1}],"oa_status":"closed","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjlb.36.6.771","host_type":"publisher"},{"url":"https://academic.oup.com/jleukbio/article-pdf/36/6/771/49724009/jlb0771.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1002/jlb.36.6.771","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6438263","host_type":"repository"}],"fields_of_study":["Fungal Biology and Applications","Bacterial biofilms and quorum sensing","3D Printing in Biomedical Research","Animals","Cells, Cultured","Kinetics","Macrophages","Male","Mice","Mice, Inbred C57BL","Phagocytosis","Polysaccharides, Bacterial","Pseudomonas aeruginosa","Saccharomyces cerevisiae"],"mesh_terms":["Animals","Cells, Cultured","Kinetics","Macrophages","Male","Mice, Inbred C57BL","Phagocytosis","Polysaccharides, Bacterial","Pseudomonas aeruginosa","Saccharomyces cerevisiae","Mice"],"keywords":["Phagocytosis","Phagocyte","Microbiology","Biology","Macrophage","Pseudomonas aeruginosa","Virulence","Yeast","Polysaccharide","Virulence factor","In vivo","Saccharomyces cerevisiae","In vitro","Biochemistry","Bacteria"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T22:34:25.016103Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}