{"doi":"10.1002/jlb.1ma0720-654rr","title":"CD56dimCD57−NKG2C+ NK cells retaining proliferative potential are possible precursors of CD57+NKG2C+ memory-like NK cells","abstract":"Abstract Formation of the adaptive-like NK cell subset in response to HCMV infection is associated with epigenetic rearrangements, accompanied by multiple changes in the protein expression. This includes a decrease in the expression level of the adapter chain FcεRIγ, NKp30, and NKG2A receptors and an increase in the expression of NKG2C receptor, some KIR family receptors, and co-stimulating molecule CD2. Besides, adaptive-like NK cells are characterized by surface expression of CD57, a marker of highly differentiated cells. Here, it is shown that CD57-negative CD56dimNKG2C+ NK cells may undergo the same changes, as established by the similarity of the phenotypic expression pattern with that of the adaptive-like CD57+NKG2C+ NK cells. Regardless of their differentiation stage, NKG2C-positive NK cells had increased HLA-DR expression indicating an activated state, both ex vivo and after cultivation in stimulating conditions. Additionally, CD57−NKG2C+ NK cells exhibited better proliferative activity compared to CD57+NKG2C+ and NKG2C− NK cells, while retaining high level of natural cytotoxicity. Thus, CD57−NKG2C+ NK cells may represent a less differentiated, but readily expanding stage of the adaptive-like CD57+NKG2C+ NK cells. Moreover, it is shown that NK cells have certain phenotypic plasticity and may both lose NKG2C expression and acquire it de novo during proliferation, induced by IL-2 and K562-mbIL21 feeder cells.","journal":"Journal of Leukocyte Biology","year":2020,"id":97326,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":481360,"name":"Maria A. Streltsova","orcid":"0000-0002-5403-0753","position":1,"is_corresponding":false},{"id":482143,"name":"Sofya A. Erokhina","orcid":null,"position":2,"is_corresponding":false},{"id":481361,"name":"Leonid M. Kanevskiy","orcid":"0000-0002-6378-774X","position":3,"is_corresponding":false},{"id":481362,"name":"William G. Telford","orcid":"0009-0002-2689-9600","position":4,"is_corresponding":false},{"id":481363,"name":"Alexander M. Sapozhnikov","orcid":"0000-0002-4934-677X","position":5,"is_corresponding":false},{"id":481364,"name":"Elena I. Kovalenko","orcid":"0000-0001-8119-8247","position":6,"is_corresponding":false},{"id":482142,"name":"Polina A. Kobyzeva","orcid":null,"position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-18T22:35:34.520494Z","pmid":"32930385","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}