{"doi":"10.1002/jia2.26168","title":"Sexual and drug use risk behaviour trajectories among people treated for recent HCV infection: the REACT study","abstract":"INTRODUCTION: Exploration of sexual and drug use behaviours following treatment for recent hepatitis C virus (HCV) is limited. This analysis modelled behavioural trajectories following treatment for recent HCV and assessed reinfection. METHODS: Participants treated for recent HCV in an international trial (enrolled 2017-2019) were followed at 3-monthly intervals for up to 2 years to assess longitudinal behaviours. Population-averaged changes were assessed using generalized estimating equations. Distinct behavioural trajectories were identified using group-based trajectory modelling. HCV reinfection incidence was calculated using person-years (PY) of observation. RESULTS: During the follow-up of 212 participants (84% gay and bisexual men [GBM]; 69% HIV; 26% current injecting drug use [IDU]), behavioural trajectories for IDU and stimulant use (past month) did not change. However, population-averaged decreases in the likelihood of daily IDU (adjusted odds ratio [AOR] 0.83; 95% CI 0.72, 0.95) and opioid use (AOR 0.84; 95% CI 0.75, 0.93) were observed. Among GBM, behavioural trajectories for chemsex did not change. Population-averaged decreases in condomless anal intercourse with casual male partners (CAI-CMP) (AOR 0.95; 95% CI 0.90, 0.99) and group-sex (AOR 0.86; 95% CI 0.80, 0.93) were observed, but masked distinct trajectories. While a proportion had a decreased probability of CAI-CMP (23%) and group-sex (59%) post-treatment, a substantial proportion retained a high probability of these behaviours. High HCV reinfection incidence was observed for the sustained high probability IDU (33.0/100 PY; 95% CI 17.7, 61.3) and chemsex (23.3/100 PY; 95% CI 14.5, 37.5) trajectories. CONCLUSIONS: Limited sexual and drug use behavioural change was observed following treatment for recent HCV, supporting access to surveillance and (re)treatment.","journal":"Journal of the International AIDS Society","year":2023,"id":375497,"datarank":0.2587086580756316,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.01729297121051654,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.01729297121051654,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":2,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8742,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02625909"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":680334,"name":"Sebastiano Barbieri","orcid":"0000-0002-5919-372X","position":1,"is_corresponding":false},{"id":638072,"name":"Evan B. Cunningham","orcid":"0000-0002-8048-3473","position":2,"is_corresponding":false},{"id":1061422,"name":"Eric Mao","orcid":"0000-0001-9967-4790","position":3,"is_corresponding":false},{"id":12057,"name":"Marc van der Valk","orcid":"0000-0002-8290-6425","position":4,"is_corresponding":false},{"id":28609,"name":"Jürgen K. Rockstroh","orcid":"0000-0003-2858-3888","position":5,"is_corresponding":false},{"id":328319,"name":"Margaret Hellard","orcid":"0000-0002-5055-3266","position":6,"is_corresponding":false},{"id":237353,"name":"Arthur Y. Kim","orcid":"0000-0003-4712-2657","position":7,"is_corresponding":false},{"id":664988,"name":"Sanjay Bhagani","orcid":"0000-0003-2557-4337","position":8,"is_corresponding":false},{"id":28335,"name":"Jordan J. Feld","orcid":"0000-0003-2640-2211","position":9,"is_corresponding":false},{"id":665647,"name":"Ed Gane","orcid":null,"position":10,"is_corresponding":false},{"id":664991,"name":"Maria Christine Thurnheer","orcid":"0000-0003-1357-0347","position":11,"is_corresponding":false},{"id":430982,"name":"Julie Bruneau","orcid":"0000-0002-3484-6456","position":12,"is_corresponding":false},{"id":664990,"name":"Elise Tu","orcid":"0000-0001-5762-3012","position":13,"is_corresponding":false},{"id":301350,"name":"Gregory J. Dore","orcid":"0000-0002-4741-2622","position":14,"is_corresponding":false},{"id":390621,"name":"Gail Matthews","orcid":"0000-0002-1048-6396","position":15,"is_corresponding":false},{"id":302840,"name":"Marianne Martinello","orcid":"0000-0001-9444-0186","position":16,"is_corresponding":false},{"id":1138506,"name":"the REACT study group","orcid":null,"position":17,"is_corresponding":false},{"id":1083554,"name":"Joanne Carson","orcid":"0000-0001-8043-0200","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T01:16:23.381203Z","pmid":"37675828","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}