{"doi":"10.1002/jia2.25588","title":"Uptake and retention on HIV pre‐exposure prophylaxis among key and priority populations in South‐Central Uganda","abstract":"INTRODUCTION: Pre-exposure prophylaxis (PrEP) programmes have been initiated in sub-Saharan Africa to prevent HIV acquisition in key populations at increased risk. However, data on PrEP uptake and retention in high-risk African communities are limited. We evaluated PrEP uptake and retention in HIV hyperendemic fishing villages and trading centres in south-central Uganda between April 2018 and March 2019. METHODS: PrEP eligibility was assessed using a national risk screening tool. Programme data were used to evaluate uptake and retention over 12 months. Multivariable modified Poisson regression estimated adjusted prevalence ratios (aPR) and 95% Confidence intervals (CIs) of uptake associated with covariates. We used Kaplan-Meier analysis to estimate retention and multivariable Cox regression to estimate adjusted relative hazards (aRH) and 95% CIs of discontinuation associated with covariates. RESULTS AND DISCUSSION: Of the 2985 HIV-negative individuals screened; 2750 (92.1 %) were eligible; of whom 2,536 (92.2%) accepted PrEP. Male (aPR = 0.91, 95% CI = 0.85 to 0.97) and female (aPR = 0.85, 95% CI = 0.77 to 0.94) fisher folk were less likely to accept compared to HIV-discordant couples. Median retention was 45.4 days for both men and women, whereas retention was higher among women (log rank, p < 0.001) overall. PrEP discontinuation was higher among female sex workers (aRH = 1.42, 95% CI = 1.09 to 1.83) and female fisher folk (aRH = 1.99, 95% CI = 1.46 to 2.72), compared to women in discordant couples. Male fisher folk (aRH = 1.37, 95% CI = 1.07 to 1.76) and male truck drivers (aRH = 1.49, 95% CI = 1.14 to 1.94) were more likely to discontinue compared to men in discordant couples. Women 30 to 34 years tended to have lower discontinuation rates compared to adolescents 15 to 19 years (RH = 0.78 [95% CI = 0.63 to 0.96]). CONCLUSIONS: PrEP uptake was high, but retention was very low especially among those at the highest risk of HIV: fisher folk, sex workers and truck drivers and adolescent girls. Research on reasons for PrEP discontinuation could help optimize retention.","journal":"Journal of the International AIDS Society","year":2020,"id":57655,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":77,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.902,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":303237,"name":"James Batte","orcid":null,"position":1,"is_corresponding":false},{"id":301534,"name":"Hadijja Nakawooya","orcid":"0000-0002-0566-547X","position":2,"is_corresponding":false},{"id":303238,"name":"Boniface Kigozi","orcid":null,"position":3,"is_corresponding":false},{"id":301535,"name":"Gertrude Nakigozi","orcid":"0000-0001-6193-2790","position":4,"is_corresponding":false},{"id":301536,"name":"Susanne Strömdahl","orcid":"0000-0002-6706-0177","position":5,"is_corresponding":false},{"id":301537,"name":"Anna Mia Ekström","orcid":"0000-0002-3912-1171","position":6,"is_corresponding":false},{"id":301538,"name":"Larry W. Chang","orcid":"0000-0001-7985-4567","position":7,"is_corresponding":false},{"id":303239,"name":"Ron Gray","orcid":null,"position":8,"is_corresponding":false},{"id":301539,"name":"Steven J. Reynolds","orcid":"0000-0002-5403-2759","position":9,"is_corresponding":false},{"id":303240,"name":"Patrick Komaketch","orcid":null,"position":10,"is_corresponding":false},{"id":301540,"name":"Stella Alamo","orcid":"0000-0003-4404-1181","position":11,"is_corresponding":false},{"id":301541,"name":"David Serwadda","orcid":"0000-0001-6532-6587","position":12,"is_corresponding":false},{"id":301533,"name":"Joseph Kagaayi","orcid":"0000-0003-4101-3038","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-18T21:06:48.611399Z","pmid":"32785976","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}