{"doi":"10.1002/jha2.995","title":"Feasibility of intravenous vitamin C supplementation in allogeneic hematopoietic cell transplant recipients","abstract":"Abstract Introduction Intravenous vitamin C was administered following hematopoietic stem cell transplant to mitigate nonrelapse mortality (NRM) in a Phase II clinical trial. Methods Patients with advanced hematologic malignancies received IV vitamin C, 50 mg/kg/day, in three divided doses on days 1–14 after HSCT, followed by 500 mg bid oral until 6 months. Results All patients enrolled (55) were deficient in vitamin C at day 0 and had restoration to normal levels. Vitamin C recipients had a trend for lower nonrelapse mortality (NRM, 11% vs. 25%, p ‐value = 0.07) compared with propensity score‐matched historical controls. A similar trend toward improved survival was observed (82% vs. 62% p = 0.06), with no attributable grade 3 and 4 toxicities to vitamin C. Conclusion In patients undergoing allogeneic HSCT, repletion of vitamin C is feasible and may reduce NRM and improve overall survival. Randomized trials in large uniform cohorts of patients are needed to confirm the utility of this easily available and inexpensive therapy.","journal":"eJHaem","year":2024,"id":471726,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9367,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":384729,"name":"Roy Sabo","orcid":"0000-0001-9159-4876","position":1,"is_corresponding":false},{"id":540983,"name":"Rehan Qayyum","orcid":"0000-0003-3086-8014","position":2,"is_corresponding":false},{"id":779974,"name":"May Aziz","orcid":null,"position":3,"is_corresponding":false},{"id":733986,"name":"Erika G. Martin","orcid":"0000-0003-2607-8933","position":4,"is_corresponding":false},{"id":1173894,"name":"Robyn J. Bernard","orcid":null,"position":5,"is_corresponding":false},{"id":650108,"name":"Manjari Sriparna","orcid":"0000-0003-3272-7370","position":6,"is_corresponding":false},{"id":1173896,"name":"Cody McIntire","orcid":null,"position":7,"is_corresponding":false},{"id":545479,"name":"Elizabeth Krieger","orcid":"0000-0002-8728-3327","position":8,"is_corresponding":false},{"id":1173514,"name":"Donald F. Brophy","orcid":"0000-0003-3447-8523","position":9,"is_corresponding":false},{"id":848544,"name":"Ramesh Natarajan","orcid":"0000-0002-3431-9971","position":10,"is_corresponding":false},{"id":541245,"name":"Alpha A. Fowler","orcid":"0000-0002-1445-8800","position":11,"is_corresponding":false},{"id":1306501,"name":"Catherine H. Roberts","orcid":"0000-0002-9748-6523","position":12,"is_corresponding":false},{"id":545480,"name":"Amir A. Toor","orcid":"0000-0001-5317-8433","position":13,"is_corresponding":false},{"id":779582,"name":"Gary Simmons","orcid":"0000-0002-4724-4956","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-19T02:05:48.788780Z","pmid":"39415933","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}