{"doi":"10.1002/jha2.42","title":"Spirometry use in patients with sickle cell disease with and without asthma and acute chest syndrome: A multicenter study","abstract":"A de-identified data repository of electronic medical record (EMR) data, i2b2 (Informatics for Integrating Biology and the Bedside), including 4 geographically diverse academic medical centers, was queried to determine the use of diagnostic spirometry testing in African American children and young adults 5-34 years old with sickle cell disease (SCD) with or without a documented history of asthma and/or acute chest syndrome (ACS). A total of 2,749 patients were identified with SCD, of these 577 had asthma and 409 had ACS. Cross-referencing the CPT code for diagnostic spirometry showed that for patients identified as having SCD, a history or ACS, and a diagnosis of asthma, only 31% across all 4 centers had spirometry. Having an asthma diagnosis was associated with ACS. Among SCD patients with asthma, the proportion with ACS for the four centers was 47%, 75%, 38%, and 36% respectively. The bivariate association between asthma and ACS for each Center was significant for each (p<.001). To summarize, only one third of patients with co-morbid SCD, ACS, and asthma received the spirometry procedure as recommended in evidence-based guidelines, suggesting limited testing for changes in pulmonary function. Future studies to determine barriers and facilitators to implementation of pulmonary testing in SCD are warranted.","journal":"eJHaem","year":2020,"id":113345,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5574,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":535816,"name":"Lucien Vandy Black","orcid":null,"position":1,"is_corresponding":false},{"id":535071,"name":"Dima Ezmigna","orcid":"0000-0002-9250-5932","position":2,"is_corresponding":false},{"id":535072,"name":"Jeanette F. Green","orcid":"0000-0001-5746-3178","position":3,"is_corresponding":false},{"id":524051,"name":"Yingwei Yao","orcid":"0000-0001-5389-2717","position":4,"is_corresponding":false},{"id":38128,"name":"Shaun J. Grannis","orcid":"0000-0002-8093-6639","position":5,"is_corresponding":false},{"id":535817,"name":"Jeff Klann","orcid":null,"position":6,"is_corresponding":false},{"id":276390,"name":"Reuben Applegate","orcid":null,"position":7,"is_corresponding":false},{"id":535818,"name":"Gigi Lipori","orcid":null,"position":8,"is_corresponding":false},{"id":535073,"name":"Tanya Wallace‐Farquharson","orcid":"0000-0003-2712-9595","position":9,"is_corresponding":false},{"id":445397,"name":"Diana J. Wilkie","orcid":"0000-0002-3954-8933","position":10,"is_corresponding":false},{"id":535070,"name":"Laurie Duckworth","orcid":"0000-0002-8205-3266","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-18T23:13:21.458038Z","pmid":"32924025","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}