{"doi":"10.1002/jez.361","title":"Differential expression and dynamic changes of SOX3 during gametogenesis and sex reversal in protogynous hermaphroditic fish","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    SOX3 has been suggested to play significant roles in gametogenesis and gonad differentiation of vertebrates, but the exact cellular localization evidence is insufficient and controversial. In this study, a protogynous hermaphrodite fish\n                    <jats:italic>Epinephelus coioides</jats:italic>\n                    is selected to analyze\n                    <jats:italic>EcSox3</jats:italic>\n                    differential expression and the expression pattern in both processes of oogenesis and spermatogenesis by utilizing the advantages that gonad development undergoes transition from ovary to intersexual gonad and then to testis, and primordial germ cells and different stage cells during oogenesis and spermatogenesis are synchronously observed in the transitional gonads. The detailed and clear immunofluoresence localization indicates that significantly differential expression and dynamic changes of\n                    <jats:italic>Sox3</jats:italic>\n                    occur in the progresses of gametogenesis and sex reversal, and\n                    <jats:italic>Ec</jats:italic>\n                    SOX3 protein exists in the differentiating primordial germ cells, oogonia, and different stage oocytes of ovaries, and also in the differentiating primordial germ cells and the Sertoli cells of testis. One important finding is that the\n                    <jats:italic>EcSox3</jats:italic>\n                    expression is a significant time point for enterable gametogenesis of primordial germ cells because\n                    <jats:italic>Ec</jats:italic>\n                    SOX3 is obviously expressed and localized in primordial germ cells. As\n                    <jats:italic>EcSox3</jats:italic>\n                    continues to express, the\n                    <jats:italic>Ec</jats:italic>\n                    SOX3‐positive primordial germ cells develop toward oogonia and then oocytes, whereas when\n                    <jats:italic>EcSox3</jats:italic>\n                    expression is ceased, the\n                    <jats:italic>Ec</jats:italic>\n                    SOX3‐positive primordial germ cells develop toward spermatogonia. Therefore, the current finding of\n                    <jats:italic>Ec</jats:italic>\n                    SOX3 in the differentiating primordial germ cells again confirms the potential regulatory role in oogenesis and germ cell differentiation. The data further suggest that SOX3, as a transcription factor, might have more important roles in oogenesis than in spermatogenesis.\n                    <jats:italic>J. Exp. Zool. 307A:207–219, 2007</jats:italic>\n                    . © 2007 Wiley‐Liss, Inc.\n                  </jats:p>","journal":"Journal of Experimental Zoology Part A: Ecological Genetics and Physiology","year":2007,"id":42513,"datarank":2.415262726546276,"base_score":4.356708826689592,"endowment":4.356708826689592,"self_citation_contribution":0.6535063240034389,"citation_network_contribution":1.761756402542837,"self_endowment_contribution":0.6535063240034389,"citer_contribution":1.761756402542837,"corpus_percentile":null,"corpus_rank":null,"citation_count":77,"citer_count":64,"citers_with_citation_signal":53,"citers_with_endowment":53,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":141851,"name":"Li Zhou","orcid":null,"position":1,"is_corresponding":false},{"id":45531,"name":"Yang Wang","orcid":"0000-0001-9385-7393","position":2,"is_corresponding":false},{"id":134097,"name":"Wei Xia","orcid":null,"position":3,"is_corresponding":false},{"id":203388,"name":"Jian‐Fang Gui","orcid":null,"position":4,"is_corresponding":false},{"id":203387,"name":"Bo Yao","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.356708826689592,"endowment":4.356708826689592,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17436330","pmcid":null,"openalex_id":"https://openalex.org/W2157444467","authors":[],"funders":[],"total_grants":0,"fwci":2.1818,"citation_percentile":0.88795242,"influential_citations":1,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":16},{"year":2015,"count":2},{"year":2016,"count":3},{"year":2017,"count":3},{"year":2018,"count":5},{"year":2019,"count":3},{"year":2020,"count":4},{"year":2021,"count":6},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2025,"count":4}],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjez.361","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jez.361","host_type":"publisher"},{"url":"https://doi.org/10.1002/jez.361","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17436330","host_type":"repository"}],"fields_of_study":["Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","Reproductive biology and impacts on aquatic species","Sperm and Testicular Function","Biology","Medicine","Animals","Antibody Specificity","Bass","DNA-Binding Proteins","Female","Gametogenesis","Gene Expression Regulation","Hermaphroditic Organisms","High Mobility Group Proteins","Male","Oocytes","Ovary","SOXB1 Transcription Factors","Sertoli Cells","Sex Determination Processes","Sex Differentiation","Testis","Transcription Factors"],"mesh_terms":["Animals","Antibody Specificity","Bass","DNA-Binding Proteins","Female","Gametogenesis","Gene Expression Regulation","High Mobility Group Proteins","Male","Oocytes","Ovary","Sertoli Cells","Sex Differentiation","Testis","Transcription Factors","Sex Determination Processes","SOXB1 Transcription Factors","Hermaphroditic Organisms"],"keywords":["Gametogenesis","Biology","Oogenesis","Gonad","Germ line development","Spermatogenesis","Cell biology","Germ plasm","Germ cell","Embryo","Genetics","Endocrinology","Oocyte","Embryogenesis","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-14T03:25:10.450736Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}