{"doi":"10.1002/jez.1402650403","title":"The role of organic osmolytes in osmoregulation: From bacteria to mammals","abstract":"<jats:title>Abstract</jats:title><jats:p>Cells of marine species are known to establish osmotic balance with their environment by adjusting the concentrations of organic osmolytes rather than inorganic osmolytes such as sodium, potassium, and chloride. These organic osmolytes fall into three classes: polyhydric alcohols such as sorbitol, amino acids and amino acid derivatives, and urea and trimethylamines. Substantial evidence is available for a central role of each of these classes in osmoregulation in marine species. In this chapter information on the importance of organic osmolytes is extended to a study of isolated mammalian kidney cells. The intracellular concentration of organic osmolytes in these cells responds dramatically to changes in the osmotic environment. The release of sorbitol following hypoosmotic exposure appears to be triggered by calcium, possibly via a mechanism involving membrane recycling. The summarized experiments provide a basis for further work in marine species. © 1993 Wiley‐Liss, Inc.</jats:p>","journal":"Journal of Experimental Zoology","year":1993,"id":667806,"datarank":0.6573039952010823,"base_score":4.382026634673881,"endowment":4.382026634673881,"self_citation_contribution":0.6573039952010823,"citation_network_contribution":0.0,"self_endowment_contribution":0.6573039952010823,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":79,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1743887,"name":"Rolf K. H. 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The intracellular concentration of organic osmolytes in these cells responds dramatically to changes in the osmotic environment. The release of sorbitol following hypoosmotic exposure appears to be triggered by calcium, possibly via a mechanism involving membrane recycling. The summarized experiments provide a basis for further work in marine species. © 1993 Wiley‐Liss, Inc.</jats:p>","is_dataset_classified":null,"base_score":4.382026634673881,"endowment":4.382026634673881,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8463791","pmcid":null,"openalex_id":"https://openalex.org/W2102917649","authors":[],"funders":[],"total_grants":0,"fwci":7.835,"citation_percentile":0.98373984,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":2},{"year":2022,"count":3},{"year":2023,"count":4},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjez.1402650403","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jez.1402650403","host_type":"publisher"},{"url":"https://doi.org/10.1002/jez.1402650403","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8463791","host_type":"repository"}],"fields_of_study":["Aquaculture Nutrition and Growth","Physiological and biochemical adaptations","Marine Bivalve and Aquaculture Studies","Animals","Bacteria","Calcium","Cell Membrane","Mammals","Sorbitol","Water-Electrolyte Balance"],"mesh_terms":["Animals","Bacteria","Calcium","Cell Membrane","Mammals","Sorbitol","Water-Electrolyte Balance"],"keywords":["Osmolyte","Osmoregulation","Sorbitol","Chemistry","Potassium","Osmoprotectant","Biochemistry","Betaine","Sodium","Osmotic shock","Amino acid","Intracellular Fluid","Ectoine","Biology","Intracellular","Proline","Salinity","Ecology","Organic chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T19:04:33.150321Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}