{"doi":"10.1002/jcp.29550","title":"miRNA‐192 and ‐215 activate Wnt/β‐catenin signaling pathway in gastric cancer via APC","abstract":"Although great progress has been made in surgical techniques, traditional radiotherapy, and chemotherapy, gastric cancer (GC) is still the most common malignant tumor and has a high mortality, which highlights the importance of novel diagnostic markers. Emerging studies suggest that different microRNAs (miRNAs) are involved in tumorigenesis of GC. In this study, we found that miRNA-192 and -215 are significantly upregulated in GC and promote cell proliferation and migration. Adenomatous polyposis coli (APC), a well-known negative regulator in Wnt signaling, has been proved to be a target of miRNA-192 and -215. Inhibition of miRNA-192 or -215 reduced the Topflash activities and repressed the expression of Wnt signaling pathway proteins, while APC small interfering RNAs reversed the inhibitory effects, suggesting that miRNA-192 and -215 activate Wnt signaling via APC. In addition, APC mediates the cell proliferation and migration regulated by miRNA-192 and -215. Furthermore, APC is downregulated in GC tissues and negatively correlated with the expression of miRNA-192 and -215. In summary, miRNA-192 and -215 target APC and function as oncogenic miRNAs by activating Wnt signaling in GC, revealing to be potential therapeutic targets.","journal":"Journal of Cellular Physiology","year":2020,"id":91677,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":459050,"name":"Xiaojing Zhang","orcid":"0000-0002-4964-0960","position":1,"is_corresponding":false},{"id":77435,"name":"Ying� Qin","orcid":"0000-0003-4365-586X","position":2,"is_corresponding":false},{"id":459051,"name":"Wangchun Chen","orcid":"0000-0001-8468-7142","position":3,"is_corresponding":false},{"id":459052,"name":"Fan Hu","orcid":"0000-0003-3521-5696","position":4,"is_corresponding":false},{"id":459053,"name":"Xianling Feng","orcid":"0000-0002-9097-3345","position":5,"is_corresponding":false},{"id":252142,"name":"Jian Wang","orcid":"0000-0002-9482-5227","position":6,"is_corresponding":false},{"id":460247,"name":"Ruibin Yan","orcid":null,"position":7,"is_corresponding":false},{"id":395278,"name":"Yanqiu Zhao","orcid":"0000-0001-7925-3606","position":8,"is_corresponding":false},{"id":459054,"name":"Yulan Cheng","orcid":"0009-0005-9438-3181","position":9,"is_corresponding":false},{"id":459055,"name":"Yanjie Wei","orcid":"0000-0002-4791-7540","position":10,"is_corresponding":false},{"id":460248,"name":"Xinmin Fan","orcid":null,"position":11,"is_corresponding":false},{"id":341377,"name":"Hassan Ashktorab","orcid":"0000-0002-4048-4666","position":12,"is_corresponding":false},{"id":460249,"name":"Duane T. Smoot","orcid":null,"position":13,"is_corresponding":false},{"id":459056,"name":"Stephen J. Meltzer","orcid":"0000-0002-9131-1052","position":14,"is_corresponding":false},{"id":459057,"name":"Song Li","orcid":"0000-0002-0661-4893","position":15,"is_corresponding":false},{"id":459058,"name":"Kuan Li","orcid":"0000-0001-7662-3093","position":16,"is_corresponding":false},{"id":459059,"name":"Yin Peng","orcid":"0000-0001-7524-7508","position":17,"is_corresponding":false},{"id":459060,"name":"Zhe Jin","orcid":"0000-0001-7911-7970","position":18,"is_corresponding":false},{"id":459049,"name":"Shiqi Deng","orcid":"0000-0002-2128-1521","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T22:29:21.932251Z","pmid":"32091625","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}