{"doi":"10.1002/jcp.29419","title":"Identification of tRNA‐derived small RNA (tsRNA) responsive to the tumor suppressor, RUNX1, in breast cancer","abstract":"Despite recent advances in targeted therapies, the molecular mechanisms driving breast cancer initiation, progression, and metastasis are minimally understood. Growing evidence indicate that transfer RNA (tRNA)-derived small RNAs (tsRNA) contribute to biological control and aberrations associated with cancer development and progression. The runt-related transcription factor 1 (RUNX1) transcription factor is a tumor suppressor in the mammary epithelium whereas RUNX1 downregulation is functionally associated with breast cancer initiation and progression. We identified four tsRNA (ts-19, ts-29, ts-46, and ts-112) that are selectively responsive to expression of the RUNX1 tumor suppressor. Our finding that ts-112 and RUNX1 anticorrelate in normal-like mammary epithelial and breast cancer lines is consistent with tumor-related activity of ts-112 and tumor suppressor activity of RUNX1. Inhibition of ts-112 in MCF10CA1a aggressive breast cancer cells significantly reduced proliferation. Ectopic expression of a ts-112 mimic in normal-like mammary epithelial MCF10A cells significantly increased proliferation. These findings support an oncogenic potential for ts-112. Moreover, RUNX1 may repress ts-112 to prevent overactive proliferation in breast epithelial cells to augment its established roles in maintaining the mammary epithelium.","journal":"Journal of Cellular Physiology","year":2020,"id":55748,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":90,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":290360,"name":"Stephanie Scalia","orcid":null,"position":1,"is_corresponding":false},{"id":288840,"name":"Caroline Adams","orcid":"0000-0001-6028-0196","position":2,"is_corresponding":false},{"id":248815,"name":"Deli Hong","orcid":null,"position":3,"is_corresponding":false},{"id":288841,"name":"Andrew J. Fritz","orcid":"0000-0002-2220-9943","position":4,"is_corresponding":false},{"id":288842,"name":"Terri Messier","orcid":"0000-0002-4381-5694","position":5,"is_corresponding":false},{"id":290361,"name":"Veronica Balatti","orcid":null,"position":6,"is_corresponding":false},{"id":290362,"name":"Dario Veneziano","orcid":null,"position":7,"is_corresponding":false},{"id":288843,"name":"Jane B. Lian","orcid":"0000-0001-8683-9138","position":8,"is_corresponding":false},{"id":247626,"name":"Carlo M. Croce","orcid":"0000-0003-3788-1457","position":9,"is_corresponding":false},{"id":49920,"name":"Gary S. Stein","orcid":"0000-0001-8762-5422","position":10,"is_corresponding":false},{"id":147373,"name":"Janet L. Stein","orcid":null,"position":11,"is_corresponding":false},{"id":288839,"name":"Nicholas H. Farina","orcid":"0000-0002-6061-590X","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-18T21:05:29.672878Z","pmid":"31919859","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}