{"doi":"10.1002/jcp.27799","title":"Long noncoding RNA LINC00460 promotes carcinogenesis via sponging miR‐613 in papillary thyroid carcinoma","abstract":"<jats:title>Abstract</jats:title><jats:p>Long intergenic noncoding RNA 460 (LINC00460) has been identified as a critical regulator for multiple types of cancers. However, the biological role and underlying mechanism in human papillary thyroid carcinoma (PTC) still remain unclear and need to be uncovered. This study was aimed to ascertain the biological role and molecular mechanism of LINC00460 in PTC progression. Our findings revealed that the level of LINC00460 was significantly upregulated in PTC tissues and cell lines, which was positively correlated with advanced tumor–node–metastasis (TNM) stage and lymph node metastasis. Cellular experiments exhibited that knockdown of LINC00460 decreased proliferative, migratory, and invasive abilities of PTC cells. Mechanism assays noted that knockdown of LINC00460 suppressed cell proliferation, migration, and invasion, and inhibited expression of sphingosine kinase 2 (SphK2, a target of miR‐613) in PTC cells, at least in part, by regulating miR‐613. These findings suggested that LINC00460 could function as a competing endogenous RNA to regulate SphK2 expression by sponging miR‐613 in PTC. Targeting LINC00460 could be a promising therapeutic strategy for patients with PTC.</jats:p>","journal":"Journal of Cellular Physiology","year":2019,"id":629244,"datarank":0.5244761342199721,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.0,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1393036,"name":"Bin Yang","orcid":"0000-0003-1947-8058","position":1,"is_corresponding":false},{"id":1629508,"name":"Xiao‐Di Tang","orcid":"0000-0002-6114-6789","position":2,"is_corresponding":false},{"id":1053134,"name":"Li Feng","orcid":"0000-0001-6991-6509","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Long noncoding RNA LINC00460 promotes carcinogenesis via sponging miR‐613 in papillary thyroid carcinoma","abstract":"<jats:title>Abstract</jats:title><jats:p>Long intergenic noncoding RNA 460 (LINC00460) has been identified as a critical regulator for multiple types of cancers. However, the biological role and underlying mechanism in human papillary thyroid carcinoma (PTC) still remain unclear and need to be uncovered. This study was aimed to ascertain the biological role and molecular mechanism of LINC00460 in PTC progression. Our findings revealed that the level of LINC00460 was significantly upregulated in PTC tissues and cell lines, which was positively correlated with advanced tumor–node–metastasis (TNM) stage and lymph node metastasis. Cellular experiments exhibited that knockdown of LINC00460 decreased proliferative, migratory, and invasive abilities of PTC cells. Mechanism assays noted that knockdown of LINC00460 suppressed cell proliferation, migration, and invasion, and inhibited expression of sphingosine kinase 2 (SphK2, a target of miR‐613) in PTC cells, at least in part, by regulating miR‐613. These findings suggested that LINC00460 could function as a competing endogenous RNA to regulate SphK2 expression by sponging miR‐613 in PTC. Targeting LINC00460 could be a promising therapeutic strategy for patients with PTC.</jats:p>","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30478856","pmcid":null,"openalex_id":"https://openalex.org/W2902987895","authors":[],"funders":[],"total_grants":0,"fwci":1.5041,"citation_percentile":0.81094094,"influential_citations":0,"citation_trend":[{"year":2019,"count":3},{"year":2020,"count":13},{"year":2021,"count":6},{"year":2022,"count":6},{"year":2023,"count":2},{"year":2024,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1002/jcp.27799","host_type":"journal"},{"url":"https://doi.org/10.1002/jcp.27799","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjcp.27799","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcp.27799","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jcp.27799","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30478856","host_type":"repository"}],"fields_of_study":["Cancer-related molecular mechanisms research","Circular RNAs in diseases","RNA Research and Splicing","Carcinoma, Papillary","Cell Line, Tumor","Cell Movement","Cell Proliferation","Gene Expression Regulation, Neoplastic","Gene Knockdown Techniques","Humans","MicroRNAs","Phosphotransferases (Alcohol Group Acceptor)","RNA, Long Noncoding","RNA, Untranslated","Thyroid Gland","Thyroid Neoplasms","Up-Regulation","Sphingosine Kinase"],"mesh_terms":["Sphingosine Kinase","Carcinoma, Papillary","Cell Movement","Humans","Thyroid Gland","Thyroid Neoplasms","Up-Regulation","Gene Expression Regulation, Neoplastic","Phosphotransferases (Alcohol Group Acceptor)","RNA, Untranslated","MicroRNAs","Cell Line, Tumor","Cell Proliferation","Gene Knockdown Techniques","RNA, Long Noncoding"],"keywords":["Gene knockdown","Cancer research","Downregulation and upregulation","Biology","Long non-coding RNA","Carcinogenesis","Cell growth","Thyroid carcinoma","Metastasis","Cancer","Cell culture","Endocrinology","Thyroid","Gene","Papillary Thyroid Carcinoma","Sphk2","Mir-613","Lncrna Linc00460"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.12671263.v1","title":"Additional file 1 of Identification of a three-long noncoding RNA prognostic model involved competitive endogenous RNA in kidney renal clear cell carcinoma","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.12671263","title":"Additional file 1 of Identification of a three-long noncoding RNA prognostic model involved competitive endogenous RNA in kidney renal clear cell carcinoma","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T17:43:04.892984Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}