{"doi":"10.1002/jcla.23627","title":"Virulence factors impair epithelial junctions during bacterial infection","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Epithelial cells are typically connected through different types of cell junctions that are localized from the apical membrane to the basal surface. In this way, epithelium cells form the first barrier against pathogenic microorganisms and prevent their entry into internal organs and the circulatory system. Recent studies demonstrate that bacterial pathogens disrupt epithelial cell junctions through targeting junctional proteins by secreted virulence factors. In this review, we discuss the diverse strategies used by common bacterial pathogens, including\n                    <jats:italic>Pseudomonas aeruginosa</jats:italic>\n                    ,\n                    <jats:italic>Helicobacter pylori</jats:italic>\n                    , and enteropathogenic\n                    <jats:italic>Escherichia coli</jats:italic>\n                    , to disrupt epithelial cell junctions during infection. We also discuss the potential of targeting the pathogenic mechanisms in the treatment of pathogen‐associated diseases.\n                  </jats:p>","journal":"Journal of Clinical Laboratory Analysis","year":2021,"id":609381,"datarank":0.515098080672772,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.0,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":796041,"name":"Shuang Sun","orcid":"0000-0001-5297-6222","position":1,"is_corresponding":false},{"id":951931,"name":"Jun Zhou","orcid":"0000-0003-4519-6433","position":2,"is_corresponding":false},{"id":250181,"name":"Min Liu","orcid":"0000-0001-7095-1344","position":3,"is_corresponding":false},{"id":1386300,"name":"Manxi Zheng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Virulence factors impair epithelial junctions during bacterial infection","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Epithelial cells are typically connected through different types of cell junctions that are localized from the apical membrane to the basal surface. In this way, epithelium cells form the first barrier against pathogenic microorganisms and prevent their entry into internal organs and the circulatory system. Recent studies demonstrate that bacterial pathogens disrupt epithelial cell junctions through targeting junctional proteins by secreted virulence factors. In this review, we discuss the diverse strategies used by common bacterial pathogens, including\n                    <jats:italic>Pseudomonas aeruginosa</jats:italic>\n                    ,\n                    <jats:italic>Helicobacter pylori</jats:italic>\n                    , and enteropathogenic\n                    <jats:italic>Escherichia coli</jats:italic>\n                    , to disrupt epithelial cell junctions during infection. We also discuss the potential of targeting the pathogenic mechanisms in the treatment of pathogen‐associated diseases.\n                  </jats:p>","is_dataset_classified":null,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33070380","pmcid":"PMC7891540","openalex_id":"https://openalex.org/W3092988310","authors":[],"funders":[{"funder_name":"Natural Science Foundation of Shandong Province","grant_id":"ZR2018BC002","title":null},{"funder_name":"China Postdoctoral Science Foundation","grant_id":"2017M622257","title":null}],"total_grants":2,"fwci":2.0,"citation_percentile":0.84419942,"influential_citations":0,"citation_trend":[{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":4},{"year":2024,"count":3},{"year":2025,"count":12},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcla.23627","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcla.23627","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcla.23627","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jcla.23627","host_type":"publisher"},{"url":"https://doi.org/10.1002/jcla.23627","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33070380","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7891540","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7891540","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7891540?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Escherichia coli research studies","Clostridium difficile and Clostridium perfringens research","Vibrio bacteria research studies"],"mesh_terms":["Bacterial Infections","Escherichia coli Infections","Humans","Intercellular Junctions","Pseudomonas aeruginosa","Pseudomonas Infections","Helicobacter pylori","Helicobacter Infections","Virulence Factors","Enteropathogenic Escherichia coli","Host-Pathogen Interactions"],"keywords":["Virulence","Pseudomonas aeruginosa","Microbiology","Epithelium","Biology","Pathogen","Tight junction","Enteropathogenic Escherichia coli","Cell","Cell biology","Bacterial cell structure","Bacterial outer membrane","Escherichia coli","Bacteria","Gene","Genetics","Infection","Epithelial cell","Cell junction","Virulence factor","Adherens Junction","Bacterial Pathogen"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T07:11:57.772646Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}