{"doi":"10.1002/jca.20062","title":"The number of CD34+ cells in peripheral blood as a predictor of the CD34+ yield in patients going to autologous stem cell transplantation","abstract":null,"journal":"Journal of Clinical Apheresis","year":2006,"id":671997,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1755640,"name":"P. Abichain","orcid":null,"position":1,"is_corresponding":false},{"id":1755641,"name":"J.C. Damonte","orcid":null,"position":2,"is_corresponding":false},{"id":1755642,"name":"B. Ricchi","orcid":null,"position":3,"is_corresponding":false},{"id":1755643,"name":"A.G. Sturich","orcid":null,"position":4,"is_corresponding":false},{"id":1755644,"name":"E.D. Palazzo","orcid":null,"position":5,"is_corresponding":false},{"id":1755645,"name":"J.J. García","orcid":null,"position":6,"is_corresponding":false},{"id":1755638,"name":"A.L. Basquiera","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The number of CD34+ cells in peripheral blood as a predictor of the CD34+ yield in patients going to autologous stem cell transplantation","abstract":"The number of CD34(+) cells in peripheral blood (PB) is a guide to the optimal timing to harvest peripheral blood progenitor cells (PBPC). The objective was to determine the number of CD34(+) cells in PB that allows achieving a final apheresis product containing > or =1.5 x 10(6) CD34(+) cells/kg, performing up to three aphereses. Between March 1999 and August 2003, patients with hematological and solid malignancies who underwent leukapheresis for autologous bone marrow transplantation were prospectively evaluated. Seventy-two aphereses in 48 patients were performed (mean 1.45 per patient; range 1-3). PBPC were mobilized with cyclophosphamide plus recombinant human granulocyte-colony stimulating factor (G-CSF) (n = 40), other chemotherapy drugs plus G-CSF (n = 7), or G-CSF alone (n = 1). We found a strong correlation between the CD34(+) cells count in peripheral blood and the CD34(+) cells yielded (r = 0.903; P < 0.0001). Using receiver-operating characteristic (ROC) curves, the minimum number of CD34(+) cells in PB to obtain > or =1.5 x 10(6)/kg in the first apheresis was 16.48 cells/microL (sensitivity 100%; specificity 95%). The best cut-off point necessary to obtain the same target in the final harvest was 15.48 cells/microL, performing up to three aphereses (sensitivity 89%; specificity 100%). In our experience, > or =15 CD34(+) cells/microL is the best predictor to begin the apheresis procedure. Based on this threshold level, it is possible to achieve at least 1.5 x 10(6)/kg CD34(+) cells in the graft with < or =3 collections.","is_dataset_classified":null,"base_score":3.912023005428146,"endowment":3.912023005428146,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16106446","pmcid":null,"openalex_id":"https://openalex.org/W2065938780","authors":[],"funders":[],"total_grants":0,"fwci":0.2853,"citation_percentile":0.56088163,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":3},{"year":2014,"count":3},{"year":2015,"count":3},{"year":2016,"count":4},{"year":2017,"count":3},{"year":2018,"count":4},{"year":2019,"count":3},{"year":2020,"count":4},{"year":2021,"count":2},{"year":2023,"count":2},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjca.20062","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full/10.1002/jca.20062","host_type":"publisher"},{"url":"https://doi.org/10.1002/jca.20062","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16106446","host_type":"repository"}],"fields_of_study":["Hematopoietic Stem Cell Transplantation","Multiple Myeloma Research and Treatments","Platelet Disorders and Treatments","Adolescent","Adult","Aged","Antigens, CD34","Blood Cells","Bone Marrow Transplantation","Child","Child, Preschool","Female","Hematopoietic Stem Cell Mobilization","Hematopoietic Stem Cells","Humans","Leukapheresis","Male","Middle Aged","Neoplasms","Peripheral Blood Stem Cell Transplantation","Predictive Value of Tests","Prospective Studies","ROC Curve","Transplantation, Autologous"],"mesh_terms":["Adolescent","Adult","Aged","Blood Cells","Child","Child, Preschool","Female","Hematopoietic Stem Cells","Humans","Leukapheresis","Male","Middle Aged","Neoplasms","Predictive Value of Tests","Prospective Studies","ROC Curve","Transplantation, Autologous","Bone Marrow Transplantation","Antigens, CD34","Hematopoietic Stem Cell Mobilization","Peripheral Blood Stem Cell Transplantation"],"keywords":["Medicine","CD34","Peripheral blood","Transplantation","Stem cell","Peripheral","Peripheral Blood Stem Cells","Yield (engineering)","Immunology","Internal medicine","Hematopoietic stem cell transplantation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T05:47:38.340687Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}