{"doi":"10.1002/jbt.10069","title":"Hepatoprotection by <scp>L</scp>‐cysteine‐glutathione mixed disulfide, a sulfhydryl‐modified prodrug of glutathione","abstract":"<jats:title>Abstract</jats:title><jats:p><jats:sc>L</jats:sc>‐Cysteine‐glutathione disulfide, a ubiquitous substance present in mammalian cells, was shown to be highly effective in protecting mice against acetaminophen‐induced hepatotoxicity. Since the corresponding <jats:sc>D</jats:sc>‐cysteine‐glutathione disulfide was totally ineffective in this regard, an enzymatic mechanism that provides glutathione directly to cells is postulated. © 2003 Wiley Periodicals, Inc. J Biochem Mol Toxicol 17:95–97, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). 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