{"doi":"10.1002/jbmr.4308","title":"The Antiresorptive Effect of GIP, But Not GLP-2, Is Preserved in Patients With Hypoparathyroidism—A Randomized Crossover Study","abstract":"Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted postprandially. In healthy humans, both hormones decrease bone resorption accompanied by a rapid reduction in parathyroid hormone (PTH). The aim of this study was to investigate whether the changes in bone turnover after meal intake and after GIP- and GLP-2 injections, respectively, are mediated via a reduction in PTH secretion. This was tested in female patients with hypoparathyroidism given a standardized liquid mixed-meal test (n = 7) followed by a peptide injection test (n = 4) using a randomized crossover design. We observed that the meal- and GIP- but not the GLP-2-induced changes in bone turnover markers were preserved in the patients with hypoparathyroidism. To understand the underlying mechanisms, we examined the expression of the GIP receptor (GIPR) and the GLP-2 receptor (GLP-2R) in human osteoblasts and osteoclasts as well as in parathyroid tissue. The GIPR was expressed in both human osteoclasts and osteoblasts, whereas the GLP-2R was absent or only weakly expressed in osteoclasts. Furthermore, both GIPR and GLP-2R were expressed in parathyroid tissue. Our findings suggest that the GIP-induced effect on bone turnover may be mediated directly via GIPR expressed in osteoblasts and osteoclasts and that this may occur independent of PTH. In contrast, the effect of GLP-2 on bone turnover seems to depend on changes in PTH and may be mediated through GLP-2R in the parathyroid gland. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).","journal":"Journal of Bone and Mineral Research","year":2020,"id":98219,"datarank":0.5289540786924243,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"self_citation_contribution":0.5289540786924243,"citation_network_contribution":0.0,"self_endowment_contribution":0.5289540786924243,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":484870,"name":"Nicola Hepp","orcid":"0000-0003-4571-0439","position":1,"is_corresponding":false},{"id":485718,"name":"Jannika Oeke","orcid":null,"position":2,"is_corresponding":false},{"id":484871,"name":"Morten Steen Hansen","orcid":"0000-0001-8269-8542","position":3,"is_corresponding":false},{"id":292706,"name":"Abbas Jafari","orcid":"0000-0003-2443-6231","position":4,"is_corresponding":false},{"id":484872,"name":"Maria S. Svane","orcid":"0000-0002-7345-4471","position":5,"is_corresponding":false},{"id":397802,"name":"Nariman Balenga","orcid":"0000-0002-2741-9595","position":6,"is_corresponding":false},{"id":273923,"name":"John A. Olson","orcid":"0000-0002-5183-6890","position":7,"is_corresponding":false},{"id":485719,"name":"Morten Frost","orcid":null,"position":8,"is_corresponding":false},{"id":241937,"name":"Moustapha Kassem","orcid":"0000-0003-1557-0869","position":9,"is_corresponding":false},{"id":484873,"name":"Sten Madsbad","orcid":"0000-0002-5017-1815","position":10,"is_corresponding":false},{"id":484874,"name":"Jens‐Erik Beck Jensen","orcid":"0000-0003-4290-0480","position":11,"is_corresponding":false},{"id":226898,"name":"Jens J. Holst","orcid":"0000-0001-6853-3805","position":12,"is_corresponding":false},{"id":226901,"name":"Mette M. Rosenkilde","orcid":"0000-0001-9600-3254","position":13,"is_corresponding":false},{"id":484875,"name":"Bolette Hartmann","orcid":"0000-0001-8509-2036","position":14,"is_corresponding":false},{"id":484869,"name":"Kirsa Skov‐Jeppesen","orcid":"0000-0002-8861-6699","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T22:36:34.157932Z","pmid":"33852173","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}