{"doi":"10.1002/jbmr.10","title":"Infrared spectroscopy indicates altered bone turnover and remodeling activity in renal osteodystrophy","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Renal osteodystrophy alters metabolic activity and remodeling rate of bone and also may lead to different bone composition. The objective of this study was to characterize the composition of bone in high-turnover renal osteodystrophy patients by means of Fourier transform infrared spectroscopic imaging (FTIRI). Iliac crest biopsies from healthy bone (n = 11) and patients with renal osteodystrophy (ROD, n = 11) were used in this study. The ROD samples were from patients with hyperparathyroid disease. By using FTIRI, phosphate-to-amide I ratio (mineral-to-matrix ratio), carbonate-to-phosphate ratio, and carbonate-to-amide I ratio (turnover rate/remodeling activity), as well as the collagen cross-link ratio (collagen maturity), were quantified. Histomorphometric analyses were conducted for comparison. The ROD samples showed significantly lower carbonate-to-phosphate (p &amp;lt; .01) and carbonate-to-amide I (p &amp;lt; .001) ratios. The spatial variation across the trabeculae highlighted a significantly lower degree of mineralization (p &amp;lt; .05) at the edges of the trabeculae in the ROD samples than in normal bone. Statistically significant linear correlations were found between histomorphometric parameters related to bone-remodeling activity and number of bone cells and FTIRI-calculated parameters based on carbonate-to-phosphate and carbonate-to-amide I ratios. Hence the results suggested that FTIRI parameters related to carbonate may be indicative of turnover and remodeling rate of bone. © 2010 American Society for Bone and Mineral Research</jats:p>","journal":"Journal of Bone and Mineral Research","year":2010,"id":674327,"datarank":0.6610078870896381,"base_score":4.406719247264253,"endowment":4.406719247264253,"self_citation_contribution":0.6610078870896381,"citation_network_contribution":0.0,"self_endowment_contribution":0.6610078870896381,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":81,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1761844,"name":"Mikael J Turunen","orcid":null,"position":1,"is_corresponding":false},{"id":1761845,"name":"Lassi Rieppo","orcid":null,"position":2,"is_corresponding":false},{"id":328618,"name":"Simo Saarakkala","orcid":"0000-0003-2850-5484","position":3,"is_corresponding":false},{"id":1761846,"name":"Inari S Tamminen","orcid":null,"position":4,"is_corresponding":false},{"id":1761847,"name":"Jarno Rieppo","orcid":null,"position":5,"is_corresponding":false},{"id":633808,"name":"Heikki Kröger","orcid":null,"position":6,"is_corresponding":false},{"id":1761848,"name":"Jukka S Jurvelin","orcid":null,"position":7,"is_corresponding":false},{"id":1761843,"name":"Hanna Isaksson","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Infrared spectroscopy indicates altered bone turnover and remodeling activity in renal osteodystrophy","abstract":"<jats:title>Abstract</jats:title>\n               <jats:p>Renal osteodystrophy alters metabolic activity and remodeling rate of bone and also may lead to different bone composition. The objective of this study was to characterize the composition of bone in high-turnover renal osteodystrophy patients by means of Fourier transform infrared spectroscopic imaging (FTIRI). Iliac crest biopsies from healthy bone (n = 11) and patients with renal osteodystrophy (ROD, n = 11) were used in this study. The ROD samples were from patients with hyperparathyroid disease. By using FTIRI, phosphate-to-amide I ratio (mineral-to-matrix ratio), carbonate-to-phosphate ratio, and carbonate-to-amide I ratio (turnover rate/remodeling activity), as well as the collagen cross-link ratio (collagen maturity), were quantified. Histomorphometric analyses were conducted for comparison. The ROD samples showed significantly lower carbonate-to-phosphate (p &amp;lt; .01) and carbonate-to-amide I (p &amp;lt; .001) ratios. The spatial variation across the trabeculae highlighted a significantly lower degree of mineralization (p &amp;lt; .05) at the edges of the trabeculae in the ROD samples than in normal bone. Statistically significant linear correlations were found between histomorphometric parameters related to bone-remodeling activity and number of bone cells and FTIRI-calculated parameters based on carbonate-to-phosphate and carbonate-to-amide I ratios. Hence the results suggested that FTIRI parameters related to carbonate may be indicative of turnover and remodeling rate of bone. © 2010 American Society for Bone and Mineral Research</jats:p>","is_dataset_classified":null,"base_score":4.406719247264253,"endowment":4.406719247264253,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20200925","pmcid":null,"openalex_id":"https://openalex.org/W1994288361","authors":[],"funders":[{"funder_name":"European Commission FP7","grant_id":"FP7_219980","title":null},{"funder_name":"Research Council of Finland","grant_id":"128863","title":"Assessment of Bone Quality in Metabolic Bone Diseases"},{"funder_name":"Research Council of Finland","grant_id":"127198","title":"Novel Minimally Invasive Quantitative Ultrasound Techniques for Diagnostics of Osteoarthritis"},{"funder_name":"European Commission","grant_id":"219980","title":"Assessment of Bone Quality in Metabolic Bone Diseases"}],"total_grants":4,"fwci":3.8681,"citation_percentile":0.92975042,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":7},{"year":2014,"count":6},{"year":2015,"count":7},{"year":2016,"count":6},{"year":2017,"count":9},{"year":2018,"count":5},{"year":2019,"count":8},{"year":2020,"count":6},{"year":2021,"count":7},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":4},{"year":2025,"count":3}],"oa_status":"closed","license":"OUP Standard Publication Reuse","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbmr.10","host_type":"publisher"},{"url":"https://academic.oup.com/jbmr/article-pdf/25/6/1360/56577972/jbmr10.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1002/jbmr.10","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20200925","host_type":"repository"},{"url":"https://lup.lub.lu.se/record/2277109","host_type":"repository"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbmr.10","host_type":""},{"url":"https://dx.doi.org/10.1002/jbmr.10","host_type":""}],"fields_of_study":["Bone health and osteoporosis research","Vitamin D Research Studies","Bone and Dental Protein Studies","0301 basic medicine","0303 health sciences","03 medical and health sciences","Adult","Biopsy","Bone Remodeling","Bone and Bones","Chronic Kidney Disease-Mineral and Bone Disorder","Humans","Male","Spectroscopy, Fourier Transform Infrared"],"mesh_terms":["Adult","Biopsy","Bone and Bones","Humans","Male","Chronic Kidney Disease-Mineral and Bone Disorder","Bone Remodeling","Spectroscopy, Fourier Transform Infrared"],"keywords":["Bone remodeling","Renal osteodystrophy","Chemistry","Internal medicine","Endocrinology","Carbonate","Bone mineral","Mineralization (soil science)","Phosphate","Medicine","Biochemistry","Osteoporosis","Kidney disease","Adult","Chronic Kidney Disease-Mineral and Bone Disorder","Male","Biopsy","Spectroscopy, Fourier Transform Infrared","Humans","Bone and Bones"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T16:28:33.189803Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}