{"doi":"10.1002/jbm.a.38006","title":"Silver (I) and Silver ( <scp>II</scp> ) Oxide Films for Biomedical Implants: Synthesis, Stability, Ion Release, and Antibacterial Efficacy","abstract":"ABSTRACT Coatings of silver compounds with higher dissolution rates than metallic silver offer a promising approach for delivering Ag + ions to prevent medical implant device‐associated infections. In this study, we investigate the synthesis and characterization of single‐phase, silver (I) oxide (Ag 2 O) and silver (II) oxide (AgO) for potential antimicrobial applications. The synthesis of these materials leverages the higher stability of Ag 2 O in comparison to AgO. The formation of AgO requires a low landing energy of the adatoms, achieved through gas phase scattering and rapid quenching when landing. Alternatively, higher landing energies cause re‐sputtering of oxygen, which favors the formation of Ag 2 O. Higher chamber pressures during deposition increase the number of inelastic collisions, thereby reducing the energy of the adatoms influencing phase formation. A combination of energy dispersive spectroscopy, microstructural imaging, X‐ray diffraction (XRD), and high‐temperature XRD confirms this result. To evaluate antimicrobial potential, silver ion release (elution) was measured in water, Luria‐Bertani broth, and tryptic soy broth. Elution rates were highest in water, but in all media, both oxides elute significantly more Ag + ions than metallic silver coatings. Antimicrobial assays clearly show potent and broad‐spectrum activity of silver oxides against both clinical and multidrug‐resistant bacteria, confirming their potential as effective antimicrobial coatings for implanted devices.","journal":"Journal of Biomedical Materials Research Part A","year":2025,"id":548017,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1441248,"name":"H. Maurer","orcid":null,"position":1,"is_corresponding":false},{"id":360687,"name":"Matthew W. Urban","orcid":"0000-0003-1360-4287","position":2,"is_corresponding":false},{"id":1441249,"name":"Steven DiSpirito","orcid":null,"position":3,"is_corresponding":false},{"id":1440766,"name":"G. Torres","orcid":"0000-0003-1551-2570","position":4,"is_corresponding":false},{"id":1441250,"name":"Arwa M Muhamed","orcid":null,"position":5,"is_corresponding":false},{"id":1441251,"name":"Janiyah Harris","orcid":null,"position":6,"is_corresponding":false},{"id":1441252,"name":"Alex Bharath","orcid":null,"position":7,"is_corresponding":false},{"id":1344940,"name":"R.J. Green","orcid":null,"position":8,"is_corresponding":false},{"id":1441253,"name":"T. H. Scabarozi","orcid":null,"position":9,"is_corresponding":false},{"id":445450,"name":"Gregory A. Caputo","orcid":"0000-0002-4510-2815","position":10,"is_corresponding":false},{"id":1028379,"name":"Valerie J. Carabetta","orcid":"0000-0002-2211-0556","position":11,"is_corresponding":false},{"id":1440767,"name":"J. D. Hettinger","orcid":"0000-0002-9371-1236","position":12,"is_corresponding":false},{"id":1028377,"name":"Maxwell Akantibila","orcid":"0009-0006-3672-4280","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-19T02:53:53.962932Z","pmid":"41144936","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}