{"doi":"10.1002/jbm.a.37378","title":"Pegylated insulin‐like growth factor‐1 biotherapeutic delivery promotes rotator cuff regeneration in a rat model","abstract":"Tears in the rotator cuff are challenging to repair because of the complex, hypocellular, hypovascular, and movement-active nature of the tendon and its enthesis. Insulin-like Growth Factor-1 (IGF-1) is a promising therapeutic for this repair. However, its unstable nature, short half-life, and ability to disrupt homeostasis has limited its clinical translation. Pegylation has been shown to improve the stability and sustain IGF-1 levels in the systemic circulation without disrupting homeostasis. To provide localized delivery of IGF-1 in the repaired tendons, we encapsulated pegylated IGF-1 mimic and its controls (unpegylated IGF-1 mimic and recombinant human IGF-1) in polycaprolactone-based matrices and evaluated them in a pre-clinical rodent model of rotator cuff repair. Pegylated-IGF-1 mimic delivery reestablished the characteristic tendon-to-bone enthesis structure and improved tendon tensile properties within 8 weeks of repair compared to controls, signifying the importance of pegylation in this complex tissue regeneration. These results demonstrate a simple and scalable biologic delivery technology alternative to tissue-derived grafts for soft tissue repair.","journal":"Journal of Biomedical Materials Research Part A","year":2022,"id":253312,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9475,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":360678,"name":"Varadraj N. Vernekar","orcid":"0000-0001-6277-7868","position":1,"is_corresponding":false},{"id":883223,"name":"Caldon Jayson Esdaille","orcid":"0000-0002-9425-4954","position":2,"is_corresponding":false},{"id":898783,"name":"Ellen Eisenberg","orcid":"0000-0003-2307-6780","position":3,"is_corresponding":false},{"id":885562,"name":"Amir Lebaschi","orcid":"0000-0003-1580-774X","position":4,"is_corresponding":false},{"id":377957,"name":"Mary Badon","orcid":null,"position":5,"is_corresponding":false},{"id":266939,"name":"Amir Seyedsalehi","orcid":"0000-0002-2296-5247","position":6,"is_corresponding":false},{"id":898784,"name":"Godwin K. Dzidotor","orcid":"0000-0002-2839-0616","position":7,"is_corresponding":false},{"id":360677,"name":"Xiaoyan Tang","orcid":"0000-0001-9199-5346","position":8,"is_corresponding":false},{"id":232254,"name":"Nathaniel A. Dyment","orcid":"0000-0001-8708-112X","position":9,"is_corresponding":false},{"id":646928,"name":"Stavros Thomopoulos","orcid":"0000-0003-1531-4849","position":10,"is_corresponding":false},{"id":250006,"name":"Sangamesh G. Kumbar","orcid":"0000-0001-7672-4783","position":11,"is_corresponding":false},{"id":411167,"name":"Alix Deymier","orcid":"0000-0001-5187-4427","position":12,"is_corresponding":false},{"id":724122,"name":"Eckhard Weber","orcid":"0000-0002-1762-005X","position":13,"is_corresponding":false},{"id":242205,"name":"Cato T. Laurencin","orcid":"0000-0001-6765-3047","position":14,"is_corresponding":false},{"id":360679,"name":"Anupama Prabhath","orcid":"0009-0000-8923-7239","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T00:24:55.325369Z","pmid":"35253991","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}