{"doi":"10.1002/jbio.70037","title":"Endothelial c‐Myc and Doxorubicin‐Induced Metabolic Alterations: A Multi‐Organ Optical Imaging Study","abstract":"SIGNIFICANCE: Endothelial c-Myc plays a critical role in redox homeostasis, with its deletion potentially exacerbating oxidative stress, particularly, during chemotherapy. AIM: To assess the metabolic impact of endothelial c-Myc knockout (KO) and Doxorubicin (DOXO) treatment on kidneys, hearts, and livers using 3D optical cryo-imaging. APPROACH: Redox ratios (NADH/FAD) were analyzed in control (CT) and KO mice treated with DOXO or saline to evaluate mitochondrial function and oxidative states. RESULTS: KO tissues showed significant reductions in redox ratios, indicating an oxidized state, with kidneys exhibiting up to a 51.42% decrease. DOXO treatment further exacerbated oxidative stress in KO tissues, while CT groups demonstrated protective effects. CONCLUSIONS: Endothelial c-Myc is crucial for redox balance and protection against chemotherapy-induced oxidative damage, offering insights for targeted therapeutic strategies.","journal":"Journal of Biophotonics","year":2025,"id":540971,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8837,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1134884,"name":"Mehrnoosh Neghabi","orcid":"0000-0003-1256-4770","position":1,"is_corresponding":false},{"id":1134882,"name":"Busenur Ceyhan","orcid":"0009-0001-8549-2846","position":2,"is_corresponding":false},{"id":1253252,"name":"Jacqueline Freire Machi","orcid":null,"position":3,"is_corresponding":false},{"id":1429358,"name":"Homan A. Rahbar","orcid":null,"position":4,"is_corresponding":false},{"id":1429359,"name":"Maya S. Rodriguez","orcid":null,"position":5,"is_corresponding":false},{"id":1252755,"name":"Aline G. Santana","orcid":"0000-0001-6191-4146","position":6,"is_corresponding":false},{"id":1252757,"name":"Cláudia O. Rodrigues","orcid":"0000-0002-8416-3602","position":7,"is_corresponding":false},{"id":335081,"name":"Mahsa Ranji","orcid":"0000-0002-4185-5676","position":8,"is_corresponding":false},{"id":1134883,"name":"Parisa Nategh","orcid":"0009-0009-2974-7742","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:52:42.901627Z","pmid":"40258388","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}