{"doi":"10.1002/jbio.202500221","title":"Photonics Detection of Molecular‐Specific Spatial Structural Alterations of Cells due to Chronic Alcoholism and Probiotics Treatments in Colon Cancer","abstract":"Photonics/light localization techniques are essential in understanding the structural changes in biological cells/tissues at the nano- to sub-micron scale. It is now known that structural alterations begin at the nanoscale, marking the onset of cancer progression. This photonics study examines the molecular-specific nano-structural alterations of chronic alcoholism and probiotic effects on colon cancer using a mouse model of colon cancer. We assessed alcohol-treated and azoxymethane (AOM) with dextran sulfate sodium (DSS)-induced colitis models, including ethanol (EtOH) and probiotic (L.casei) treatments separately and together. The confocal images were analyzed using the mesoscopic physics-based Inverse Participation Ratio (IPR) technique to quantify structural alterations at nano- to submicron scales. Significant enhancement of cancer progression was observed in the EtOH-treated group, and probiotic treatment with EtOH showed substantial reversal of these changes in colon cancer, underscoring the potential of the IPR technique in detecting and monitoring cancer progression.","journal":"Journal of Biophotonics","year":2025,"id":573549,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":492177,"name":"Pradeep K. Shukla","orcid":"0000-0003-2515-9766","position":1,"is_corresponding":false},{"id":1125120,"name":"Dhruvil Solanki","orcid":"0009-0006-8507-8668","position":2,"is_corresponding":false},{"id":1359843,"name":"Santanu Maity","orcid":"0000-0001-6220-8163","position":3,"is_corresponding":false},{"id":492178,"name":"Radhakrishna Rao","orcid":"0000-0002-5906-8371","position":4,"is_corresponding":false},{"id":529931,"name":"Prabhakar Pradhan","orcid":"0000-0003-4363-2326","position":5,"is_corresponding":false},{"id":1125119,"name":"Ishmael Apachigawo","orcid":"0009-0006-9791-8898","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T02:57:32.445190Z","pmid":"40874676","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}