{"doi":"10.1002/jbio.202400078","title":"Virtual‐point‐based deconvolution for optical‐resolution photoacoustic microscopy","abstract":"Optical-resolution photoacoustic microscopy (OR-PAM) has been increasingly utilized for in vivo imaging of biological tissues, offering structural, functional, and molecular information. In OR-PAM, it is often necessary to make a trade-off between imaging depth, lateral resolution, field of view, and imaging speed. To improve the lateral resolution without sacrificing other performance metrics, we developed a virtual-point-based deconvolution algorithm for OR-PAM (VP-PAM). VP-PAM has achieved a resolution improvement ranging from 43% to 62.5% on a single-line target. In addition, it has outperformed Richardson-Lucy deconvolution with 15 iterations in both structural similarity index and peak signal-to-noise ratio on an OR-PAM image of mouse brain vasculature. When applied to an in vivo glass frog image obtained by a deep-penetrating OR-PAM system with compromised lateral resolution, VP-PAM yielded enhanced resolution and contrast with better-resolved microvessels.","journal":"Journal of Biophotonics","year":2024,"id":448848,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":257427,"name":"Anthony DiSpirito","orcid":"0000-0002-3232-7353","position":1,"is_corresponding":false},{"id":990978,"name":"Hongje Jang","orcid":"0000-0003-3987-2538","position":2,"is_corresponding":false},{"id":1268225,"name":"Colton Thomas McGarraugh","orcid":null,"position":3,"is_corresponding":false},{"id":1212602,"name":"Van Tu Nguyen","orcid":"0000-0002-4913-438X","position":4,"is_corresponding":false},{"id":454543,"name":"Lingyan Shi","orcid":"0000-0003-1373-3206","position":5,"is_corresponding":false},{"id":257434,"name":"Junjie Yao","orcid":"0000-0002-2381-706X","position":6,"is_corresponding":false},{"id":1267763,"name":"Rui Yao","orcid":"0009-0000-3710-7387","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:02:12.215092Z","pmid":"38934081","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}