{"doi":"10.1002/jbio.202400058","title":"Multiwavelength laser diode based portable photoacoustic and ultrasound imaging system for point of care applications","abstract":"Vascular diseases are a leading cause of death and disability worldwide. Despite having precursor conditions like peripheral arterial disease (PAD), they are often only diagnosed after the onset of stroke or heart attack. Low-cost, portable, noninvasive, point-of-care (POC), label-free assessment of deep vascular function benefits PAD diagnosis, especially in resource poor settings of the world. Doppler ultrasound-based blood flow measurements can diagnose PAD, albeit with limited sensitivity and specificity. To overcome this, here, we propose the first-of-its-kind dual-modality photoacoustic-and-ultrasound (PAUS) imaging system that integrates a multiwavelength pulsed laser diode (PLD) with a compact ultrasound data acquisition unit. The mesoscopic imaging depth of the portable PLD-PAUS system was validated using tissue phantoms, and its multispectral photoacoustic imaging capabilities were validated using an atherosclerosis-mimicking phantom. Furthermore, we demonstrated high-contrast volumetric in vivo photoacoustic imaging of rodent abdominal vasculature and quantified vessel reactivity due to hypercapnia stimulation. The multiparametric functional and molecular imaging capabilities of the PLD-PAUS system holds promise for POC applications.","journal":"Journal of Biophotonics","year":2024,"id":438291,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":684340,"name":"A. Haworth","orcid":null,"position":1,"is_corresponding":false},{"id":764677,"name":"Prameth Gaddale","orcid":"0000-0002-5381-8098","position":2,"is_corresponding":false},{"id":1248499,"name":"Faisal Badran","orcid":null,"position":3,"is_corresponding":false},{"id":1248500,"name":"Nuzhath Lagno","orcid":null,"position":4,"is_corresponding":false},{"id":679625,"name":"Colette R. Pameijer","orcid":"0000-0002-1967-0501","position":5,"is_corresponding":false},{"id":535033,"name":"Faisal Aziz","orcid":"0000-0002-2468-772X","position":6,"is_corresponding":false},{"id":568592,"name":"Sri‐Rajasekhar Kothapalli","orcid":"0000-0002-4010-1047","position":7,"is_corresponding":false},{"id":1117352,"name":"М. Митра","orcid":"0009-0008-3408-5176","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:00:38.888629Z","pmid":"38695390","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}