{"doi":"10.1002/jbio.202200291","title":"Intraoperative detection of<scp>IDH</scp>‐mutant glioma using fluorescence lifetime imaging","abstract":"Identifying isocitrate dehydrogenase (IDH)-mutation and glioma subtype during surgery instead of days later can aid in modifying tumor resection strategies for better survival outcomes. We report intraoperative identification of IDH-mutant glioma (N = 12 patients) with a clinically compatible fluorescence lifetime imaging (FLIm) device (excitation: 355 nm; emission spectral bands: 390/40 nm, 470/28 nm, 542/50 nm). The fluorescence-derived parameters were analyzed to study the optical contrast between IDH-mutant tumors and surrounding brain tissue. IDH-mutant oligodendrogliomas exhibited shorter lifetimes (3.3 ± 0.1 ns) than IDH-mutant astrocytomas (4.1 ± 0.1 ns). Both IDH-mutant glioma subtypes had shorter lifetimes than white matter (4.6 ± 0.4 ns) but had comparable lifetimes to cortex. Lifetimes also increased with malignancy grade within IDH-mutant oligodendrogliomas (grade 2: 2.96 ± 0.08 ns, grade 3: 3.4 ± 0.3 ns) but not within IDH-mutant astrocytomas. The current results support the feasibility of FLIm as a surgical adjuvant for identifying IDH-mutant glioma tissue.","journal":"Journal of Biophotonics","year":2022,"id":262766,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9655,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":525761,"name":"Alba Alfonso‐García","orcid":"0000-0002-6748-3751","position":1,"is_corresponding":false},{"id":659704,"name":"Xiangnan Zhou","orcid":"0000-0002-6715-5176","position":2,"is_corresponding":false},{"id":289206,"name":"Julien Bec","orcid":"0000-0003-1222-4071","position":3,"is_corresponding":false},{"id":855449,"name":"Han Sung Lee","orcid":null,"position":4,"is_corresponding":false},{"id":585338,"name":"Lee‐Way Jin","orcid":"0000-0001-9729-1032","position":5,"is_corresponding":false},{"id":618585,"name":"Orin Bloch","orcid":"0000-0001-9810-6011","position":6,"is_corresponding":false},{"id":289213,"name":"Laura Marcu","orcid":"0000-0003-2369-0748","position":7,"is_corresponding":false},{"id":918691,"name":"Silvia Noble Anbunesan","orcid":"0000-0002-5003-6322","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T00:26:25.074177Z","pmid":"36510639","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}