{"doi":"10.1002/jbio.202200231","title":"Multimodal Raman spectroscopy and optical coherence tomography for biomedical analysis","abstract":"Optical techniques hold great potential to detect and monitor disease states as they are a fast, non-invasive toolkit. Raman spectroscopy (RS) in particular is a powerful label-free method capable of quantifying the biomolecular content of tissues. Still, spontaneous Raman scattering lacks information about tissue morphology due to its inability to rapidly assess a large field of view. Optical Coherence Tomography (OCT) is an interferometric optical method capable of fast, depth-resolved imaging of tissue morphology, but lacks detailed molecular contrast. In many cases, pairing label-free techniques into multimodal systems allows for a more diverse field of applications. Integrating RS and OCT into a single instrument allows for both structural imaging and biochemical interrogation of tissues and therefore offers a more comprehensive means for clinical diagnosis. This review summarizes the efforts made to date toward combining spontaneous RS-OCT instrumentation for biomedical analysis, including insights into primary design considerations and data interpretation.","journal":"Journal of Biophotonics","year":2022,"id":245628,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":881373,"name":"Jobaida Akhtar","orcid":null,"position":1,"is_corresponding":false},{"id":880754,"name":"Erik P. Schartner","orcid":"0000-0003-1669-4302","position":2,"is_corresponding":false},{"id":880755,"name":"Heike Ebendorff‐Heidepriem","orcid":"0000-0002-4877-7770","position":3,"is_corresponding":false},{"id":321196,"name":"Anita Mahadevan‐Jansen","orcid":"0000-0002-0491-3769","position":4,"is_corresponding":false},{"id":880756,"name":"Jiawen Li","orcid":"0000-0001-8818-6070","position":5,"is_corresponding":false},{"id":321195,"name":"Sean Fitzgerald","orcid":"0000-0002-7442-5453","position":0,"is_corresponding":true}],"reference_count":137,"raw_metadata":null,"created_at":"2026-07-19T00:23:39.284121Z","pmid":"36308009","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}