{"doi":"10.1002/jat.2550020405","title":"Comparison of somatic and germ cell models for cytogenetic screening","abstract":"<jats:title>Abstract</jats:title><jats:p>A variety of <jats:italic>in vivo</jats:italic> mammalian test models are available for screening of chemicals for mutagenicity at the chromosomal level. These models have been grouped into those focusing on somatic cell effects and those dealing with germ cell effects. An analysis of available literature indicates that 76 compounds have been tested from chromosome effects in both somatic and germ cells. Of these, concordant results (positive–positive or negative–negative) were obtained with 58 compounds. Of the remaining 18 compounds with discordant results, all were positive in somatic cells, but negative in germ cell assays. These results suggest an inherent relative insensitivity of germ cells themselves to mutagenic chemicals. In the context of screening for safety evaluation purposes, this analysis suggests that a negative somatic‐cell response can be taken as highly predictive of negative results in a germ cell assessment.</jats:p>","journal":"Journal of Applied Toxicology","year":1982,"id":590976,"datarank":6.2994461416859915,"base_score":4.0943445622221,"endowment":4.0943445622221,"self_citation_contribution":0.6141516843333151,"citation_network_contribution":5.6852944573526765,"self_endowment_contribution":0.6141516843333151,"citer_contribution":5.6852944573526765,"corpus_percentile":null,"corpus_rank":null,"citation_count":59,"citer_count":59,"citers_with_citation_signal":51,"citers_with_endowment":51,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1512003,"name":"Henry E. 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These results suggest an inherent relative insensitivity of germ cells themselves to mutagenic chemicals. In the context of screening for safety evaluation purposes, this analysis suggests that a negative somatic‐cell response can be taken as highly predictive of negative results in a germ cell assessment.</jats:p>","is_dataset_classified":null,"base_score":4.0943445622221,"endowment":4.0943445622221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7185901","pmcid":null,"openalex_id":"https://openalex.org/W1992103432","authors":[],"funders":[],"total_grants":0,"fwci":0.474,"citation_percentile":0.57181719,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjat.2550020405","host_type":"publisher"},{"url":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/jat.2550020405","host_type":"publisher"},{"url":"https://doi.org/10.1002/jat.2550020405","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7185901","host_type":"repository"}],"fields_of_study":["Carcinogens and Genotoxicity Assessment","Effects and risks of endocrine disrupting chemicals","Genetically Modified Organisms Research","Animals","Germ Cells","Models, Biological","Mutagenicity Tests"],"mesh_terms":["Animals","Germ Cells","Models, Biological","Mutagenicity Tests"],"keywords":["Somatic cell","Germ cell","Biology","Context (archaeology)","Germ","Genetics","Germline","Cell","Chromosome","Cell biology","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T13:28:18.663077Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}