{"doi":"10.1002/iju5.12463","title":"Pathological complete response of plasmacytoid variant bladder cancer to pembrolizumab following genomic analysis","abstract":"<jats:sec><jats:title>Introduction</jats:title><jats:p>Plasmacytoid variant bladder cancer is a rare variant of urothelial carcinoma that accounts for 1% of bladder cancers. Plasmacytoid variant urothelial carcinoma is characterized by an aggressive phenotype and poor clinical outcomes.</jats:p></jats:sec><jats:sec><jats:title>Case presentation</jats:title><jats:p>A 61‐year‐old woman presented with gross hematuria. Cystoscopy showed a 16‐mm solid tumor. Transurethral resection of the bladder tumor was performed, and the pathological diagnosis was invasive plasmacytoid variant urothelial carcinoma. Although the pathological T stage was pT1, computed tomography showed right obturator lymph node swelling. Since previous reports indicate poor response to chemotherapy for this disease, clinical sequencing was performed. Based on the high tumor mutation burden revealed, pembrolizumab was administered for 4 cycles, and computed tomography showed a partial response. Robot‐assisted radical cystectomy was performed, and a pathological complete response including the pelvic lymph node was observed.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Pembrolizumab may be a treatment option for plasmacytoid variant urothelial carcinoma following genomic analysis.</jats:p></jats:sec>","journal":"IJU Case Reports","year":2022,"id":649940,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1694547,"name":"Satoki Tanaka","orcid":null,"position":1,"is_corresponding":false},{"id":1694548,"name":"Masafumi Maruo","orcid":null,"position":2,"is_corresponding":false},{"id":1694549,"name":"Sho Sugawara","orcid":null,"position":3,"is_corresponding":false},{"id":1694550,"name":"Kazuto Chiba","orcid":null,"position":4,"is_corresponding":false},{"id":1694551,"name":"Kanetaka Miyazaki","orcid":null,"position":5,"is_corresponding":false},{"id":1210619,"name":"Atsushi Inoue","orcid":null,"position":6,"is_corresponding":false},{"id":1694552,"name":"Tomohiko Ichikawa","orcid":null,"position":7,"is_corresponding":false},{"id":1694553,"name":"Maki Nagata","orcid":null,"position":8,"is_corresponding":false},{"id":273865,"name":"Yusuke Goto","orcid":"0000-0001-7720-9740","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pathological complete response of plasmacytoid variant bladder cancer to pembrolizumab following genomic analysis","abstract":"<jats:sec><jats:title>Introduction</jats:title><jats:p>Plasmacytoid variant bladder cancer is a rare variant of urothelial carcinoma that accounts for 1% of bladder cancers. Plasmacytoid variant urothelial carcinoma is characterized by an aggressive phenotype and poor clinical outcomes.</jats:p></jats:sec><jats:sec><jats:title>Case presentation</jats:title><jats:p>A 61‐year‐old woman presented with gross hematuria. Cystoscopy showed a 16‐mm solid tumor. Transurethral resection of the bladder tumor was performed, and the pathological diagnosis was invasive plasmacytoid variant urothelial carcinoma. Although the pathological T stage was pT1, computed tomography showed right obturator lymph node swelling. Since previous reports indicate poor response to chemotherapy for this disease, clinical sequencing was performed. Based on the high tumor mutation burden revealed, pembrolizumab was administered for 4 cycles, and computed tomography showed a partial response. Robot‐assisted radical cystectomy was performed, and a pathological complete response including the pelvic lymph node was observed.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Pembrolizumab may be a treatment option for plasmacytoid variant urothelial carcinoma following genomic analysis.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35795120","pmcid":"PMC9249653","openalex_id":"https://openalex.org/W4229439353","authors":[],"funders":[{"funder_name":"Japan Society for the Promotion of Science","grant_id":"20K22970","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"21K16753","title":null}],"total_grants":2,"fwci":1.2601,"citation_percentile":0.78256354,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1002/iju5.12463","host_type":"journal"},{"url":"https://doi.org/10.1002/iju5.12463","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/iju5.12463","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/iju5.12463","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35795120","host_type":"repository"},{"url":"https://doaj.org/article/c79b9b70303741c38f80303a428791d2","host_type":"repository"},{"url":"https://teikyo-u.repo.nii.ac.jp/records/2021041","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9249653","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9249653","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9249653?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Bladder and Urothelial Cancer Treatments","Urinary and Genital Oncology Studies","Multiple and Secondary Primary Cancers"],"mesh_terms":[],"keywords":["Medicine","Bladder cancer","Cystectomy","Pathological","Lymph node","Cystoscopy","Pathology","Cancer","Carcinoma","Urinary bladder","Oncology","Internal medicine","Plasmacytoid Variant","Pembrolizumab","High Tumor Mutation Burden"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:34:01.120914Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}