{"doi":"10.1002/ijgo.14648","title":"Antibody response, neutralizing potency, and transplacental antibody transfer following <scp>SARS‐CoV</scp>‐2 infection versus <scp>mRNA</scp>‐1273, <scp>BNT162b2 COVID</scp>‐19 vaccination in pregnancy","abstract":"OBJECTIVE: To improve our understanding of the immune response, including the neutralization antibody response, following COVID-19 vaccination in pregnancy. METHODS: This was a prospective cohort study comprising patients with PCR-confirmed SARS-CoV-2 infection and patients who received both doses of mRNA COVID-19 vaccine (mRNA-1273, BNT162b2) in pregnancy recruited from two hospitals in Atlanta, GA, USA. Maternal blood and cord blood at delivery were assayed for anti-receptor binding domain (RBD) IgG, IgA and IgM, and neutralizing antibody. The detection of antibodies, titers, and maternal to fetal transfer ratios were compared. RESULTS: Nearly all patients had detectable RBD-binding IgG in maternal and cord samples. The vaccinated versus infected cohort had a significantly greater proportion of cord samples with detectable neutralizing antibody (94% vs. 28%, P < 0.001) and significantly higher transfer ratios for RBD-specific IgG and neutralizing antibodies with a transfer efficiency of 105% (vs. 80%, P < 0.001) and 110% (vs. 90%, P < 0.001), respectively. There was a significant linear decline in maternal and cord blood RBD-specific IgG and neutralizing antibody titers as time from vaccination to delivery increased. CONCLUSIONS: Those who receive the mRNA COVID-19 vaccine mount an immune response that is equivalent to-if not greater than-those naturally infected by SARS-CoV-2 during pregnancy.","journal":"International Journal of Gynecology & Obstetrics","year":2023,"id":358864,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9534,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":52551,"name":"Naima T. Joseph","orcid":"0000-0001-6021-1609","position":1,"is_corresponding":false},{"id":1109230,"name":"Alexandra D. Forrest","orcid":"0000-0003-4573-1491","position":2,"is_corresponding":false},{"id":226159,"name":"Hans Verkerke","orcid":"0000-0002-5152-0095","position":3,"is_corresponding":false},{"id":558767,"name":"Narayanaiah Cheedarla","orcid":"0000-0001-6072-4383","position":4,"is_corresponding":false},{"id":716984,"name":"Sakthivel Govindaraj","orcid":"0000-0001-5764-6142","position":5,"is_corresponding":false},{"id":654665,"name":"Les’Shon S. Irby","orcid":"0009-0004-6574-7911","position":6,"is_corresponding":false},{"id":400086,"name":"Kirk A. Easley","orcid":"0000-0003-4419-2617","position":7,"is_corresponding":false},{"id":264426,"name":"Alicia K. Smith","orcid":"0000-0002-8537-5156","position":8,"is_corresponding":false},{"id":226169,"name":"Sean R. Stowell","orcid":"0000-0002-1130-9551","position":9,"is_corresponding":false},{"id":226168,"name":"Andrew S. Neish","orcid":"0000-0002-7090-0237","position":10,"is_corresponding":false},{"id":253824,"name":"Rama Rao Amara","orcid":"0000-0002-6309-6797","position":11,"is_corresponding":false},{"id":273917,"name":"Denise J. Jamieson","orcid":"0000-0003-2597-1201","position":12,"is_corresponding":false},{"id":292675,"name":"Anne L. Dunlop","orcid":"0000-0002-5092-8136","position":13,"is_corresponding":false},{"id":603351,"name":"Martina L. Badell","orcid":"0000-0003-1793-9666","position":14,"is_corresponding":false},{"id":280890,"name":"Vijayakumar Velu","orcid":"0000-0003-4238-1924","position":15,"is_corresponding":false},{"id":654664,"name":"Carolynn M. Dude","orcid":"0000-0002-7811-7183","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-19T01:13:48.379546Z","pmid":"36598270","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}