{"doi":"10.1002/ijgo.14552","title":"Circulating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre‐eclampsia","abstract":"OBJECTIVE: To assess and compare circulating tissue inhibitor of metalloproteinase 3 (TIMP-3) concentrations between women with pre-eclampsia and healthy pregnant women. We also aimed to determine the relationships between circulating TIMP-3 and matrix metalloproteinase 2 (MMP-2), MMP-9, TIMP-1, and TIMP-2 concentrations in pre-eclampsia. METHODS: A primary case-control study included patients with pre-eclampsia (n = 219) and gestational hypertension (n = 118), healthy pregnant women (n = 214), and non-pregnant women (n = 66), and a replication case-control study included patients with pre-eclampsia (n = 177) and healthy pregnant women (n = 124), all from southeastern Brazil. Plasma TIMP-3, MMP-2, MMP-9, TIMP-1, and TIMP-2 concentrations were assessed using commercially available enzyme-linked immunosorbent assay kits, and the relationships between them were analyzed using Spearman's correlation. RESULTS: In our primary study, patients with pre-eclampsia and gestational hypertension exhibited increased TIMP-3 concentrations compared with healthy pregnant women (both P < 0.0001) and non-pregnant women (both P < 0.001). These findings were confirmed in the replication study, showing elevated TIMP-3 concentrations in women with pre-eclampsia versus healthy pregnant women (P < 0.001). We found no difference in TIMP-3 concentrations between early-onset and late-onset pre-eclampsia. Moreover, TIMP-3 concentrations were significantly correlated with plasma concentrations of TIMP-1 (r = 0.2333; P = 0.0086) and MMP-2 (r = 0.2159; P = 0.0156) in pre-eclampsia. CONCLUSIONS: Circulating TIMP-3 concentration is increased in women with pre-eclampsia compared with healthy pregnant women, and it is positively correlated with plasma MMP-2 and TIMP-1 concentrations in pre-eclampsia.","journal":"International Journal of Gynecology & Obstetrics","year":2022,"id":282856,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8974,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":959243,"name":"Juliana de Oliveira Cruz","orcid":"0000-0002-3644-045X","position":1,"is_corresponding":false},{"id":959765,"name":"João Leandro Chaguri","orcid":null,"position":2,"is_corresponding":false},{"id":959244,"name":"José Carlos Peraçoli","orcid":"0000-0002-3273-3001","position":3,"is_corresponding":false},{"id":959245,"name":"Mariana Romão‐Veiga","orcid":"0000-0002-8990-0237","position":4,"is_corresponding":false},{"id":959766,"name":"Vanessa R. Ribeiro‐Vasques","orcid":null,"position":5,"is_corresponding":false},{"id":717924,"name":"Ricardo de Carvalho Cavalli","orcid":"0000-0001-5010-4914","position":6,"is_corresponding":false},{"id":949368,"name":"Priscila Rezeck Nunes","orcid":"0000-0002-8041-5753","position":7,"is_corresponding":false},{"id":959246,"name":"Marcelo R. Luizon","orcid":"0000-0002-8331-3525","position":8,"is_corresponding":false},{"id":717923,"name":"Valéria C. Sandrim","orcid":"0000-0002-6168-7470","position":9,"is_corresponding":false},{"id":717926,"name":"Ana C. Palei","orcid":"0000-0002-2669-5301","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T00:29:23.777809Z","pmid":"36333976","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}