{"doi":"10.1002/ijc.34810","title":"Prevalence of neoplasia at colonoscopy among testicular cancer survivors treated with platinum‐based chemotherapy","abstract":"Testicular cancer survivors (TCS) treated with platinum-based chemotherapy have an increased risk of colorectal cancer (CRC). We determined the yield of colonoscopy in TCS to assess its potential in reducing CRC incidence and mortality. We conducted a colonoscopy screening study among TCS in four Dutch hospitals to assess the yield of colorectal neoplasia. Neoplasia was defined as adenomas, serrated polyps (SPs), advanced adenomas (AAs: ≥10 mm diameter, high-grade dysplasia or ≥25% villous component), advanced serrated polyps (ASPs: ≥10 mm diameter or dysplasia) or CRC. Advanced neoplasia (AN) was defined as AA, ASP or CRC. Colonoscopy yield was compared to average-risk American males who underwent screening colonoscopy (n = 24,193) using a propensity score matched analysis, adjusted for age, smoking status, alcohol consumption and body mass index. A total of 137 TCS underwent colonoscopy. Median age was 50 years among TCS (IQR 43-57) vs 55 years (IQR 51-62) among American controls. A total of 126 TCS were matched to 602 controls. The prevalence of AN was higher in TCS than in controls (8.7% vs 1.7%; P = .0002). Nonadvanced adenomas and SPs were detected in 45.2% of TCS vs 5.5% of controls (P < .0001). No lesions were detected in 46.0% of TCS vs 92.9% of controls (P < .0001). TCS treated with platinum-based chemotherapy have a higher prevalence of neoplasia and AN than matched controls. These results support our hypothesis that platinum-based chemotherapy increases the risk of colorectal neoplasia in TCS. Cost-effectiveness studies are warranted to ascertain the threshold of AN prevalence that justifies the recommendation of colonoscopy for TCS.","journal":"International Journal of Cancer","year":2023,"id":387302,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9632,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1156085,"name":"Berbel L.M. Ykema","orcid":"0000-0002-0314-7986","position":1,"is_corresponding":false},{"id":531994,"name":"Tanya M. Bisseling","orcid":"0000-0001-7976-7949","position":2,"is_corresponding":false},{"id":1156086,"name":"Leon M.G. Moons","orcid":"0000-0002-6913-9954","position":3,"is_corresponding":false},{"id":1156087,"name":"Manon C.W. Spaander","orcid":"0000-0002-9103-9757","position":4,"is_corresponding":false},{"id":1156463,"name":"Inge L. Huibregtse","orcid":null,"position":5,"is_corresponding":false},{"id":1156464,"name":"Dorien T. J. van der Biessen‐van Beek","orcid":null,"position":6,"is_corresponding":false},{"id":1156088,"name":"Sasja F. Mulder","orcid":"0000-0002-8068-4240","position":7,"is_corresponding":false},{"id":1156465,"name":"Lisette J. Saveur","orcid":null,"position":8,"is_corresponding":false},{"id":1156089,"name":"J. Martijn Kerst","orcid":"0009-0001-5941-9792","position":9,"is_corresponding":false},{"id":1156090,"name":"Daniëlle Zweers","orcid":"0000-0002-9143-1759","position":10,"is_corresponding":false},{"id":1156091,"name":"Britt B.M. Suelmann","orcid":"0000-0002-7155-3337","position":11,"is_corresponding":false},{"id":235734,"name":"Ronald de Wit","orcid":"0000-0002-1954-090X","position":12,"is_corresponding":false},{"id":1156466,"name":"Agnes N. Reijm","orcid":null,"position":13,"is_corresponding":false},{"id":1156467,"name":"Sophia van Baalen","orcid":null,"position":14,"is_corresponding":false},{"id":490877,"name":"Lynn F. Butterly","orcid":"0000-0002-0945-3941","position":15,"is_corresponding":false},{"id":860641,"name":"William Hisey","orcid":"0000-0002-2630-4382","position":16,"is_corresponding":false},{"id":490876,"name":"Christina M. Robinson","orcid":"0000-0002-3973-0946","position":17,"is_corresponding":false},{"id":1156092,"name":"Anneke J. van Vuuren","orcid":"0000-0002-0624-3623","position":18,"is_corresponding":false},{"id":76201,"name":"Beatriz Carvalho","orcid":"0000-0003-4903-399X","position":19,"is_corresponding":false},{"id":282320,"name":"Iris Lansdorp‐Vogelaar","orcid":"0000-0002-9438-2753","position":20,"is_corresponding":false},{"id":812426,"name":"Michael Schaapveld","orcid":"0000-0003-4390-7182","position":21,"is_corresponding":false},{"id":395196,"name":"Flora E. van Leeuwen","orcid":"0000-0002-5871-1484","position":22,"is_corresponding":false},{"id":694847,"name":"Pétur Snæbjörnsson","orcid":"0000-0002-1086-8108","position":23,"is_corresponding":false},{"id":1156093,"name":"Monique E. van Leerdam","orcid":"0000-0002-5719-3208","position":24,"is_corresponding":false},{"id":1156084,"name":"Emilie C. H. Breekveldt","orcid":"0000-0002-2503-7323","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T01:18:04.706547Z","pmid":"38151749","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}