{"doi":"10.1002/ijc.33477","title":"Absence of <scp>CCR2</scp> reduces spontaneous intestinal tumorigenesis in the <scp>Apc<sup>Min</sup></scp><sup>/+</sup> mouse model","abstract":"Abstract The biological activities of chemokine (C‐C motif) ligand 2 (CCL2) are mediated via C‐C chemokine receptor‐2 (CCR2). Increased CCL2 level is associated with metastasis of many cancers. In our study, we investigated the role of the CCL2/CCR2 axis in the development of spontaneous intestinal tumorigenesis using the Apc Min/+ mouse model. Ablation of CCR2 in Apc Min/+ mice significantly increased the overall survival and reduced intestinal tumor burden. Immune cell analysis showed that CCR2 −/− Apc Min/+ mice exhibited significant reduction in the myeloid cell population and increased interferon γ (IFN‐γ) producing T cells both in spleen and mesenteric lymph nodes compared to Apc Min/+ mice. The CCR2 −/− Apc Min/+ tumors showed significantly reduced levels of interleukin (IL)‐17 and IL‐23 and increased IFN‐γ and Granzyme B compared to Apc Min/+ tumors. Transfer of CCR2 +/+ Apc Min/+ CD4 + T cells into Rag2 −/− mice led to development of colitis phenotype with increased CD4 + T cells hyper proliferation and IL‐17 production. In contrast, adoptive transfer of CCR2 −/− Apc Min/+ CD4 + T cells into Rag2 −/− mice failed to enhance colonic inflammation or IL‐17 production. These results a suggest novel additional role for CCR2, where it regulates migration of IL‐17 producing cells mediating tumor‐promoting inflammation in addition to its role in migration of tumor associated macrophages.","journal":"International Journal of Cancer","year":2021,"id":184765,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9519,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":740143,"name":"Sobha R. Bodduluri","orcid":"0000-0002-6736-3573","position":1,"is_corresponding":false},{"id":614954,"name":"Sweta Ghosh","orcid":"0000-0003-0613-8687","position":2,"is_corresponding":false},{"id":740144,"name":"Zinal Chheda","orcid":"0000-0003-4508-5944","position":3,"is_corresponding":false},{"id":241167,"name":"Rajbir Singh","orcid":"0000-0002-2307-2360","position":4,"is_corresponding":false},{"id":740654,"name":"M. Estellie Smith","orcid":null,"position":5,"is_corresponding":false},{"id":603631,"name":"Paula M. Chilton","orcid":"0000-0002-8749-0975","position":6,"is_corresponding":false},{"id":740655,"name":"Christopher Fleming","orcid":null,"position":7,"is_corresponding":false},{"id":740145,"name":"Steven Mathis","orcid":"0000-0001-7704-1220","position":8,"is_corresponding":false},{"id":740146,"name":"Rajesh Sharma","orcid":"0000-0002-3336-3006","position":9,"is_corresponding":false},{"id":3554,"name":"Rob Knight","orcid":"0000-0002-0975-9019","position":10,"is_corresponding":false},{"id":250194,"name":"Jun Yan","orcid":"0000-0003-2922-422X","position":11,"is_corresponding":false},{"id":367316,"name":"Bodduluri Haribabu","orcid":"0000-0002-8261-3294","position":12,"is_corresponding":false},{"id":497372,"name":"Venkatakrishna R. Jala","orcid":"0000-0002-4206-7305","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-18T23:48:30.970730Z","pmid":"33497467","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}