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Quantification of the HTLV‐1 proviral sequence revealed that 30 to 60 molecules were present in 10<jats:sup>5</jats:sup> peripheral‐blood mononuclear cells, indicating that the rats were chronically infected with HTLV‐1. HTLV‐1‐infected rats could serve as a small‐animal model for studying the pathophysiological state of HTLV‐1 carriers and also that of HTLV‐1 infection on various HTLV‐1‐related diseases, including adult T‐cell leukemia and HTLV‐1‐associated myelopathy.</jats:p>","journal":"International Journal of Cancer","year":1991,"id":46928,"datarank":3.029642946639947,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":2.4369563888527326,"self_endowment_contribution":0.5926865577872142,"citer_contribution":2.4369563888527326,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":44,"citers_with_citation_signal":41,"citers_with_endowment":41,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":216971,"name":"T. 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Quantification of the HTLV‐1 proviral sequence revealed that 30 to 60 molecules were present in 10<jats:sup>5</jats:sup> peripheral‐blood mononuclear cells, indicating that the rats were chronically infected with HTLV‐1. HTLV‐1‐infected rats could serve as a small‐animal model for studying the pathophysiological state of HTLV‐1 carriers and also that of HTLV‐1 infection on various HTLV‐1‐related diseases, including adult T‐cell leukemia and HTLV‐1‐associated myelopathy.</jats:p>","is_dataset_classified":null,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1682281","pmcid":null,"openalex_id":"https://openalex.org/W2099815970","authors":[],"funders":[],"total_grants":0,"fwci":1.238,"citation_percentile":0.80620641,"influential_citations":1,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":2},{"year":2020,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.2910490522","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.2910490522","host_type":"publisher"},{"url":"https://doi.org/10.1002/ijc.2910490522","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1682281","host_type":"repository"}],"fields_of_study":["T-cell and Retrovirus Studies","Animal Disease Management and Epidemiology","Vector-Borne Animal Diseases","Medicine","Biology","Animals","Base Sequence","Carrier State","Cell Line","DNA, Viral","Deltaretrovirus Infections","Disease Models, Animal","Female","HTLV-I Antibodies","HTLV-I Antigens","Human T-lymphotropic virus 1","Humans","Immunoblotting","Kinetics","Molecular Sequence Data","Polymerase Chain Reaction","Rats","Rats, Inbred F344","T-Lymphocytes"],"mesh_terms":["Animals","Base Sequence","Carrier State","Cell Line","Disease Models, Animal","DNA, Viral","Female","Deltaretrovirus Infections","Humans","Kinetics","Molecular Sequence Data","Rats, Inbred F344","T-Lymphocytes","Immunoblotting","Human T-lymphotropic virus 1","HTLV-I Antibodies","HTLV-I Antigens","Polymerase Chain Reaction","Rats"],"keywords":["Provirus","Peripheral blood mononuclear cell","Virology","T-cell leukemia","Antibody","Leukemia","Human T-lymphotropic virus","Human T-lymphotropic virus 1","Titer","Virus","Biology","Antigen","Immunology","Medicine","Myelopathy","Spinal cord","Gene","In vitro"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-14T23:51:04.965658Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}