{"doi":"10.1002/ijc.2910350402","title":"A dual expression of cytokeratin and neurofilaments in bronchial carcinoid cells","abstract":"<jats:title>Abstract</jats:title><jats:p>Intermediate filaments (IF) are ubiquitous cytoplasmic structures which, by virtue of their cell‐ and tissue‐type‐specific characteristics, are widely used as markers of tissue derivation and as differential diagnostic aids in surgical pathology. In contradistinction to other IFs, vimentin filaments, characteristic of mesenchymal cells, may be coexpressed with other cell‐type specific IFs—cytokeratin filaments, desmin filaments, glial filaments and neurofilaments—in some tumor cells, embryonic cells, and cells <jats:italic>in vitro</jats:italic>. In this study we describe a novel type of IF coexpression which does not involve vimentin‐filaments, <jats:italic>viz</jats:italic>. the presence of both cytokeratin filaments and neurofilaments in human bronchial carcinoid tumor cells.</jats:p>","journal":"International Journal of Cancer","year":1985,"id":656197,"datarank":0.5709993734655481,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"self_citation_contribution":0.5709993734655481,"citation_network_contribution":0.0,"self_endowment_contribution":0.5709993734655481,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":329927,"name":"Markku Miettinen","orcid":"0000-0002-3282-8107","position":1,"is_corresponding":false},{"id":1712949,"name":"Ismo Virtanen","orcid":null,"position":2,"is_corresponding":false},{"id":1712948,"name":"Veli‐Pekka Lehto","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A dual expression of cytokeratin and neurofilaments in bronchial carcinoid cells","abstract":"<jats:title>Abstract</jats:title><jats:p>Intermediate filaments (IF) are ubiquitous cytoplasmic structures which, by virtue of their cell‐ and tissue‐type‐specific characteristics, are widely used as markers of tissue derivation and as differential diagnostic aids in surgical pathology. In contradistinction to other IFs, vimentin filaments, characteristic of mesenchymal cells, may be coexpressed with other cell‐type specific IFs—cytokeratin filaments, desmin filaments, glial filaments and neurofilaments—in some tumor cells, embryonic cells, and cells <jats:italic>in vitro</jats:italic>. In this study we describe a novel type of IF coexpression which does not involve vimentin‐filaments, <jats:italic>viz</jats:italic>. the presence of both cytokeratin filaments and neurofilaments in human bronchial carcinoid tumor cells.</jats:p>","is_dataset_classified":null,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"2580799","pmcid":null,"openalex_id":"https://openalex.org/W1993694887","authors":[],"funders":[],"total_grants":0,"fwci":4.2043,"citation_percentile":0.94794278,"influential_citations":0,"citation_trend":[{"year":2016,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fijc.2910350402","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.2910350402","host_type":"publisher"},{"url":"https://doi.org/10.1002/ijc.2910350402","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/2580799","host_type":"repository"}],"fields_of_study":["Skin and Cellular Biology Research","Wnt/β-catenin signaling in development and cancer","Polyamine Metabolism and Applications","Bronchial Neoplasms","Carcinoid Tumor","Cytoskeleton","Electrophoresis, Polyacrylamide Gel","Fluorescent Antibody Technique","Frozen Sections","Humans","Keratins","Microscopy, Fluorescence","Peptides"],"mesh_terms":["Bronchial Neoplasms","Carcinoid Tumor","Cytoskeleton","Electrophoresis, Polyacrylamide Gel","Fluorescent Antibody Technique","Frozen Sections","Humans","Keratins","Microscopy, Fluorescence","Peptides"],"keywords":["Neurofilament","Intermediate filament","Vimentin","Cytokeratin","Desmin","Cytoplasm","Cytoskeleton","Pathology","Biology","Cell type","Cell biology","Cell","Immunohistochemistry","Medicine","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T20:06:37.392098Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}