{"doi":"10.1002/iid3.621","title":"Persistence of immune responses to the Sinopharm/BBIBP‐CorV vaccine","abstract":"BACKGROUND: To determine the kinetics and persistence of immune responses following the Sinopharm/BBIBP-CorV, we investigated immune responses in a cohort of Sri Lankan individuals. METHODS: SARS-CoV-2 specific total antibodies were measured in 20-39 years (n = 61), 40-59 years (n = 120) and those >60 years of age (n = 22) by enzyme-linked immunosorbent assay, 12 weeks after the second dose of the vaccine. Angiotensin-converting enzyme 2 (ACE2) receptor blocking antibodies (ACE2R-Ab), antibodies to the receptor-binding domain (RBD) of the ancestral virus (WT) and variants of concern, were measured in a sub cohort. T cell responses and memory B cell responses were assessed by ELISpot assays. RESULTS: A total of 193/203 (95.07%) of individuals had detectable SARS-CoV-2 specific total antibodies, while 67/110 (60.9%) had ACE2R-Ab. A total of 14.3%-16.7% individuals in the 20-39 age groups had detectable antibodies to the RBD of the WT and variants of concern, while the positivity rates of those ≥60 years of age was <10%. A total of 14/49 (28.6%) had Interferon gamma ELISpot responses to overlapping peptides of the spike protein, while memory B cell responses were detected in 9/20 to the S1 recombinant protein. The total antibody levels and ACE2R-Ab declined from 2 to 12 weeks from the second dose, while ex vivo T cell responses remained unchanged. The decline in ACE2R-Ab levels was significant among the 40-59 (p = .0007) and ≥60 (p = .005) age groups. CONCLUSIONS: Antibody responses declined in all age groups, especially in those ≥60 years, while T cell responses persisted. The effect of waning of immunity on hospitalization and severe disease should be assessed by long term efficacy studies.","journal":"Immunity Inflammation and Disease","year":2022,"id":247215,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9616,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":804527,"name":"Inoka Sepali Aberathna","orcid":"0000-0003-3365-2139","position":1,"is_corresponding":false},{"id":804528,"name":"Pradeep Darshana Pushpakumara","orcid":"0000-0002-4492-6695","position":2,"is_corresponding":false},{"id":804529,"name":"Achala Kamaladasa","orcid":"0000-0002-7179-1802","position":3,"is_corresponding":false},{"id":778396,"name":"Dinuka Guruge","orcid":"0000-0001-8670-6167","position":4,"is_corresponding":false},{"id":805051,"name":"Ayesha Wijesinghe","orcid":null,"position":5,"is_corresponding":false},{"id":805052,"name":"Banuri Gunasekera","orcid":null,"position":6,"is_corresponding":false},{"id":885249,"name":"Shyrar Tanussiya Ramu","orcid":null,"position":7,"is_corresponding":false},{"id":804530,"name":"Heshan Kuruppu","orcid":"0009-0005-8745-8202","position":8,"is_corresponding":false},{"id":804531,"name":"Thushali Ranasinghe","orcid":"0009-0007-4408-9034","position":9,"is_corresponding":false},{"id":885250,"name":"Shashika Dayarathna","orcid":null,"position":10,"is_corresponding":false},{"id":778395,"name":"Osanda Dissanayake","orcid":"0000-0001-7919-5979","position":11,"is_corresponding":false},{"id":805055,"name":"Nayanathara Gamalath","orcid":null,"position":12,"is_corresponding":false},{"id":805056,"name":"Dinithi Ekanayake","orcid":null,"position":13,"is_corresponding":false},{"id":804532,"name":"Jeewantha Jayamali","orcid":"0000-0001-9919-6290","position":14,"is_corresponding":false},{"id":804533,"name":"Deshni Jayathilaka","orcid":"0000-0002-3334-2811","position":15,"is_corresponding":false},{"id":805057,"name":"Madushika Dissanayake","orcid":null,"position":16,"is_corresponding":false},{"id":805058,"name":"Tibutius Thanesh Jayadas","orcid":null,"position":17,"is_corresponding":false},{"id":805059,"name":"Anushika Mudunkotuwa","orcid":null,"position":18,"is_corresponding":false},{"id":804534,"name":"Gayasha Somathilake","orcid":"0000-0002-1689-3881","position":19,"is_corresponding":false},{"id":778928,"name":"Michael Harvie","orcid":null,"position":20,"is_corresponding":false},{"id":805060,"name":"Thashmi Nimasha","orcid":null,"position":21,"is_corresponding":false},{"id":804535,"name":"Saubhagya Danasekara","orcid":"0000-0003-1776-5205","position":22,"is_corresponding":false},{"id":778401,"name":"Ruwan Wijayamuni","orcid":"0000-0001-5880-8684","position":23,"is_corresponding":false},{"id":555229,"name":"Lisa Schimanski","orcid":null,"position":24,"is_corresponding":false},{"id":461107,"name":"Pramila Rijal","orcid":"0000-0002-9214-9851","position":25,"is_corresponding":false},{"id":554471,"name":"Tiong Kit Tan","orcid":"0000-0001-8746-8308","position":26,"is_corresponding":false},{"id":106116,"name":"Tao Dong","orcid":"0000-0003-3545-3758","position":27,"is_corresponding":false},{"id":461108,"name":"Alain Townsend","orcid":"0000-0002-3702-0107","position":28,"is_corresponding":false},{"id":106119,"name":"Graham S. 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