{"doi":"10.1002/hsr2.495","title":"Associations between aflatoxin <scp>B<sub>1</sub></scp>‐albumin adduct levels with metabolic conditions in Guatemala: A cross‐sectional study","abstract":"Abstract Background and Aims Metabolic conditions such as obesity, type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD) are highly prevalent in Guatemala and increase the risk for a number of disorders, including hepatocellular carcinoma (HCC). Aflatoxin B 1 (AFB 1 ) levels are also notably elevated in the population and are known to be associated with HCC risk. Whether AFB 1 also contributes to the high prevalence of the metabolic disorders has not been previously examined. Therefore, the purpose of this study was to assess the association between AFB 1 and the metabolic conditions. Methods Four‐hundred twenty‐three individuals were included in the study, in which AFB 1 ‐albumin adduct levels were measured in sera. Metabolic conditions included diabetes, obesity, central obesity, metabolic syndrome, and NAFLD. Crude and adjusted prevalence odds ratios (PORs) and 95% confidence intervals (95% CI) were estimated for the associations between the metabolic conditions and AFB 1 ‐albumin adduct levels categorized into quartiles. Results The study found a significant association between AFB 1 ‐albumin adduct levels and diabetes (Q4 vs Q1 POR = 3.74, 95%CI: 1.71‐8.19; P‐trend .003). No associations were observed between AFB 1 ‐albumin adduct levels and the other conditions. Conclusions As diabetes is the metabolic condition most consistently linked to HCC, the possible association between AFB 1 exposure and diabetes may be of public health importance. Further studies are warranted to replicate the findings and examine potential mechanisms.","journal":"Health Science Reports","year":2022,"id":266342,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9602,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":482188,"name":"Alvaro Rivera‐Andrade","orcid":null,"position":1,"is_corresponding":false},{"id":482189,"name":"María F Kroker-Lobos","orcid":null,"position":2,"is_corresponding":false},{"id":234909,"name":"Andrea A. Florio","orcid":"0000-0002-5114-7083","position":3,"is_corresponding":false},{"id":405437,"name":"Joshua W. Smith","orcid":"0000-0002-8636-8097","position":4,"is_corresponding":false},{"id":492940,"name":"Patricia A. Egner","orcid":null,"position":5,"is_corresponding":false},{"id":241828,"name":"Neal D. Freedman","orcid":"0000-0003-0074-1098","position":6,"is_corresponding":false},{"id":369291,"name":"Mariana Lazo","orcid":"0000-0002-3178-6734","position":7,"is_corresponding":false},{"id":231329,"name":"Eliseo Güallar","orcid":"0000-0002-4471-9565","position":8,"is_corresponding":false},{"id":291441,"name":"Michael Dean","orcid":"0000-0003-2234-0631","position":9,"is_corresponding":false},{"id":28634,"name":"Barry I. Graubard","orcid":"0000-0002-6787-1105","position":10,"is_corresponding":false},{"id":337392,"name":"Manuel Ramírez‐Zea","orcid":"0000-0001-5107-9175","position":11,"is_corresponding":false},{"id":217919,"name":"Katherine A. McGlynn","orcid":"0000-0003-2329-9933","position":12,"is_corresponding":false},{"id":426258,"name":"John D. Groopman","orcid":"0000-0003-4690-2133","position":13,"is_corresponding":false},{"id":234911,"name":"Christian S. Álvarez","orcid":"0000-0002-5338-0444","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T00:26:54.081997Z","pmid":"35229049","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}