{"doi":"10.1002/hipo.70028","title":"Evidence of Disrupted Hippocampal Gray‐ and White‐Matter Development in Adolescent Anxiety Disorders, Independent From Early‐Life Stress","abstract":"Early-life stress and depression among youths are linked to hippocampal gray- and white-matter alterations. Less is known about hippocampal alterations in adolescent anxiety disorders (Anx) or the role that stress or comorbid depressive disorders (Anx + Dep) might play. Here, structural- and diffusion-MRI along with early-life stress-exposure reports were acquired from 197 adolescents (13.58-17.00 years) with Anx, Anx + Dep, and those without (Controls). A normative model externally validated on a large, healthy sample revealed that Anx were more likely than Controls and Anx + Dep to exhibit undersized hippocampal gray-matter volumes for their ages. Volume reductions among Anx were further localized to subfield CA1. No significant gray-matter differences were observed between Anx + Dep and Controls. Standardized probabilistic tractography in hippocampal white-matter pathways demonstrated that, relative to Controls, Anx and Anx + Dep exhibited lower fractional anisotropy specifically in the cingulum-temporal branch. All effects were specific to hippocampal structures. Group differences were not accounted for by early-life stress exposures, despite Anx and Anx + Dep reporting more than Controls. Findings indicated that gray-matter expansion, principally within CA1, may be disrupted among adolescents with anxiety disorders, but not those with comorbid depression. The progressive strengthening of hippocampal-cortical circuits occurring during adolescence may also be disrupted in adolescents with anxiety disorders, regardless of depression.","journal":"Hippocampus","year":2025,"id":545744,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7406,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":289292,"name":"Hillary Schwarb","orcid":"0000-0002-9454-2614","position":1,"is_corresponding":false},{"id":367040,"name":"Randy P. Auerbach","orcid":"0000-0003-2319-4744","position":2,"is_corresponding":false},{"id":52885,"name":"Satrajit S. Ghosh","orcid":"0000-0002-5312-6729","position":3,"is_corresponding":false},{"id":485906,"name":"Aude Henin","orcid":null,"position":4,"is_corresponding":false},{"id":243270,"name":"Stefan G. Hofmann","orcid":"0000-0002-3548-9681","position":5,"is_corresponding":false},{"id":244605,"name":"Diego A. Pizzagalli","orcid":"0000-0002-7772-1143","position":6,"is_corresponding":false},{"id":264282,"name":"Anastasia Yendiki","orcid":"0000-0003-1386-3828","position":7,"is_corresponding":false},{"id":485186,"name":"Susan Whitfield‐Gabrieli","orcid":"0000-0002-9460-167X","position":8,"is_corresponding":false},{"id":228111,"name":"John D. E. Gabrieli","orcid":"0000-0003-1158-5692","position":9,"is_corresponding":false},{"id":485903,"name":"Nicholas A. Hubbard","orcid":null,"position":10,"is_corresponding":false},{"id":1437464,"name":"Karina Pedroza‐Sotelo","orcid":null,"position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T02:53:27.751050Z","pmid":"40751564","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}