{"doi":"10.1002/hep4.1976","title":"NAFLD polygenic risk score and risk of hepatocellular carcinoma in an East Asian population","abstract":"It is difficult to identify people with nonalcoholic fatty liver disease (NAFLD) who are at high risk for developing hepatocellular carcinoma (HCC). A polygenic risk score (PRS) for hepatic fat (HFC-PRS) derived from non-Asians has been reported to be associated with HCC risk in European populations. However, population-level data of this risk in Asian populations are lacking. Utilizing resources from 24,333 participants of the Singapore Chinese Health Study (SCHS), we examined the relationship between the HFC-PRS and HCC risk. In addition, we constructed and evaluated a NAFLD-related PRS (NAFLD-PRS) with HCC risk in the SCHS. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of HCC incidence with both HFC-PRS and NAFLD-PRS. The HFC-PRS and NAFLD-PRS were highly correlated (Spearman r = 0.79, p < 0.001). The highest quartiles of both the HFC-PRS and the NAFLD-PRS were associated with significantly increased risk of HCC with HR of 2.39 (95% CI 1.51, 3.78) and 1.77 (95% CI 1.15, 2.73), respectively, compared with their respective lowest quartile. Conclusion: The PRS for hepatic fat content or NAFLD may be useful for assessing HCC risk in both Asian and European populations. The findings of this and prior studies support a potential causal role of genetically determined NAFLD in HCC development.","journal":"Hepatology Communications","year":2022,"id":243986,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9079,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":247568,"name":"Brenda Diergaarde","orcid":"0000-0002-3578-6547","position":1,"is_corresponding":false},{"id":414462,"name":"Allison L. Kuipers","orcid":"0000-0003-1415-1742","position":2,"is_corresponding":false},{"id":649241,"name":"Jennifer J. Adibi","orcid":"0000-0001-6562-8315","position":3,"is_corresponding":false},{"id":370730,"name":"Hung N. Luu","orcid":"0000-0002-2172-1849","position":4,"is_corresponding":false},{"id":236702,"name":"Xuling Chang","orcid":"0000-0001-7471-4768","position":5,"is_corresponding":false},{"id":390744,"name":"Rajkumar Dorajoo","orcid":"0000-0001-6608-2051","position":6,"is_corresponding":false},{"id":236703,"name":"Chew‐Kiat Heng","orcid":"0000-0002-7309-9473","position":7,"is_corresponding":false},{"id":90169,"name":"Chiea Chuen Khor","orcid":"0000-0002-1128-4729","position":8,"is_corresponding":false},{"id":388290,"name":"Renwei Wang","orcid":"0000-0001-8871-7054","position":9,"is_corresponding":false},{"id":430914,"name":"Aizhen Jin","orcid":"0000-0001-6375-8546","position":10,"is_corresponding":false},{"id":260003,"name":"Woon‐Puay Koh","orcid":"0000-0002-5674-6341","position":11,"is_corresponding":false},{"id":341681,"name":"Jian‐Min Yuan","orcid":"0000-0002-4620-3108","position":12,"is_corresponding":false},{"id":481667,"name":"Claire E. Thomas","orcid":"0000-0001-9515-3277","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T00:23:20.901576Z","pmid":"35503778","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}