{"doi":"10.1002/hep4.1853","title":"SARS‐CoV‐2 Infections Among Patients With Liver Disease and Liver Transplantation Who Received COVID‐19 Vaccination","abstract":"Many safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations dramatically reduce risks of coronavirus disease 2019 (COVID-19) complications and deaths. We aimed to describe cases of SARS-CoV-2 infection among patients with chronic liver disease (CLD) and liver transplant (LT) recipients with at least one prior COVID-19 vaccine dose. The SECURE-Liver and COVID-Hep international reporting registries were used to identify laboratory-confirmed COVID-19 in CLD and LT patients who received a COVID-19 vaccination. Of the 342 cases of lab-confirmed SARS-CoV-2 infections in the era after vaccine licensing, 40 patients (21 with CLD and 19 with LT) had at least one prior COVID-19 vaccination, including 12 who were fully vaccinated (≥2 weeks after second dose). Of the 21 patients with CLD (90% with cirrhosis), 7 (33%) were hospitalized, 1 (5%) was admitted to the intensive care unit (ICU), and 0 died. In the LT cohort (n = 19), there were 6 hospitalizations (32%), including 3 (16%) resulting in mechanical ventilation and 2 (11%) resulting in death. All three cases of severe COVID-19 occurred in patients who had a single vaccine dose within the last 1-2 weeks. In contemporary patients with CLD, rates of symptomatic infection, hospitalization, ICU admission, invasive ventilation, and death were numerically higher in unvaccinated individuals. Conclusion: This case series demonstrates the potential for COVID-19 infections among patients with CLD and LT recipients who had received the COVID-19 vaccination. Vaccination against SARS-CoV-2 appears to result in favorable outcomes as attested by the absence of mechanical ventilation, ICU, or death among fully vaccinated patients.","journal":"Hepatology Communications","year":2021,"id":158227,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":47,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9614,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":226671,"name":"Gwilym J. Webb","orcid":"0000-0002-0710-5644","position":1,"is_corresponding":false},{"id":226660,"name":"Ignacio García‐Juárez","orcid":"0000-0003-2400-1887","position":2,"is_corresponding":false},{"id":628757,"name":"Anand V. Kulkarni","orcid":"0000-0002-1240-1675","position":3,"is_corresponding":false},{"id":666664,"name":"Gupse Adalı","orcid":"0000-0003-2157-0304","position":4,"is_corresponding":false},{"id":404034,"name":"David Wong","orcid":"0000-0002-3310-3538","position":5,"is_corresponding":false},{"id":667331,"name":"Beth Lusina","orcid":null,"position":6,"is_corresponding":false},{"id":666665,"name":"George Ν. Dalekos","orcid":"0000-0001-7075-8464","position":7,"is_corresponding":false},{"id":241336,"name":"Steven Masson","orcid":"0000-0003-1041-9844","position":8,"is_corresponding":false},{"id":667332,"name":"Brandon M. Shore","orcid":null,"position":9,"is_corresponding":false},{"id":106107,"name":"Eleanor Barnes","orcid":"0000-0002-0860-0831","position":10,"is_corresponding":false},{"id":226670,"name":"A. Sidney Barritt","orcid":"0000-0002-4200-3256","position":11,"is_corresponding":false},{"id":226652,"name":"Thomas Marjot","orcid":"0000-0002-6542-6323","position":12,"is_corresponding":false},{"id":226653,"name":"Andrew M. Moon","orcid":"0000-0001-7163-2062","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-18T23:44:26.210708Z","pmid":"34708575","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}