{"doi":"10.1002/hep.1840010205","title":"Transferrin receptors and the uptake and release of iron by isolated hepatocytes","abstract":"<jats:sec>\n            <jats:title/>\n            <jats:p>Isolated rat hepatocytes accumulate iron from iron-transferrin by a process which is dependent on the temperature and on the transferrin concentration, and which is diminished by treatment of the cells with a proteolytic enzyme. These observations are consistent with a mechanism for iron uptake into hepatocytes involving the binding of iron-transferrin to a specific cell-surface receptor.</jats:p>\n            <jats:p>Apotransferrin is also able to bind to the hepatocyte but the apparent binding constant is about 35 times lower than that observed for the binding of iron-transferrin. The binding of apotransferrin to the cells is completely abolished by a low concentration of iron-transferrin. This suggests that the apotransferrin is binding weakly to the same receptor to which iron-transferrin binds and that there are no receptors on the surface of the hepatocyte specific for apotransferrin. In the absence of such specific-binding sites, apotransferrin may act as a passive acceptor of iron released from the hepatocyte.</jats:p>\n          </jats:sec>","journal":"Hepatology","year":1981,"id":612906,"datarank":0.7104297672591745,"base_score":4.736198448394496,"endowment":4.736198448394496,"self_citation_contribution":0.7104297672591745,"citation_network_contribution":0.0,"self_endowment_contribution":0.7104297672591745,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":113,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1578444,"name":"Philip Aisen","orcid":null,"position":1,"is_corresponding":false},{"id":1578442,"name":"Stephen P. 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This suggests that the apotransferrin is binding weakly to the same receptor to which iron-transferrin binds and that there are no receptors on the surface of the hepatocyte specific for apotransferrin. In the absence of such specific-binding sites, apotransferrin may act as a passive acceptor of iron released from the hepatocyte.</jats:p>\n          </jats:sec>","is_dataset_classified":null,"base_score":4.736198448394496,"endowment":4.736198448394496,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6269977","pmcid":null,"openalex_id":"https://openalex.org/W2035381712","authors":[],"funders":[{"funder_name":"NIADDK NIH HHS","grant_id":"AM 17702","title":null},{"funder_name":"NIADDK NIH HHS","grant_id":"AM 15056","title":null}],"total_grants":2,"fwci":4.2798,"citation_percentile":0.94653179,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":1}],"oa_status":"closed","license":"http://doi.wiley.com/10.1002/tdm_license_1.1","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.1840010205","host_type":"publisher"},{"url":"https://journals.lww.com/01515467-198103000-00004","host_type":"publisher"},{"url":"https://doi.org/10.1002/hep.1840010205","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6269977","host_type":"repository"},{"url":"https://research.birmingham.ac.uk/portal/en/publications/transferrin-receptors-and-the-uptake-and-release-of-iron-by-isolated-hepatocytes(287f4390-1b70-475f-9f4b-937f7dadd383).html","host_type":"repository"}],"fields_of_study":["Iron Metabolism and Disorders","Trace Elements in Health","Membrane-based Ion Separation Techniques","Animals","Apoproteins","Deferoxamine","In Vitro Techniques","Iron","Liver","Male","Rats","Rats, Inbred Strains","Receptors, Cell Surface","Receptors, Transferrin","Transferrin"],"mesh_terms":["Animals","Apoproteins","Deferoxamine","Iron","Liver","Male","Rats, Inbred Strains","Receptors, Cell Surface","Receptors, Transferrin","Transferrin","Rats","In Vitro Techniques"],"keywords":["Transferrin","Transferrin receptor","Hepatocyte","Chemistry","Receptor","Biochemistry","Binding site","Plasma protein binding","In vitro"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T05:33:38.935400Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}