{"doi":"10.1002/hed.70132","title":"Neutrophil to Lymphocyte and Lymphocyte to Monocyte Ratios Predict Improved Survival and Response to Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of the Larynx","abstract":"BACKGROUND: University of Michigan Cancer Center (UMCC) protocol 9520 treated stage III/IV locally advanced squamous cell carcinoma of the larynx (LASCCL) with cisplatin and 5-fluorouracil to select for definitive therapy based on response. Studies have shown that neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR) are potential prognostic markers in p16-negative LASCCL. This study analyzes the predictive value of NLR and LMR. METHODS: Samples from 193 LASCCL patients treated with chemotherapy were reviewed. Response to induction chemotherapy was tested with logistic regression. Optimal cut-points were determined by Youden's index. Survival was tested with Cox proportional hazards models. RESULTS: LMR had a positive association, NLR had a negative association with response to chemotherapy (p = 0.004;0.07). Response was higher in patients with LMR ≥ 2.8 (p = 0.0007) and NLR ≤ 2.8 (p = 0.04). Overall and disease-specific survival improved with LMR ≥ 2.8 (p = 0.0002;0.004) and NLR ≤ 2.8 (p = 0.10;0.03). CONCLUSIONS: Low NLR and high LMR were associated with favorable responses to chemotherapy and survival in LASCCL.","journal":"Head & Neck","year":2025,"id":585465,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9682,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":453229,"name":"Emily L. Bellile","orcid":"0000-0003-4350-4658","position":1,"is_corresponding":false},{"id":1498810,"name":"Moneb Bughrara","orcid":"0000-0002-1100-6518","position":2,"is_corresponding":false},{"id":376562,"name":"Paul Swiecicki","orcid":"0000-0003-2286-3555","position":3,"is_corresponding":false},{"id":383058,"name":"Keith Casper","orcid":"0000-0003-2878-3863","position":4,"is_corresponding":false},{"id":381564,"name":"Kelly M. Malloy","orcid":"0000-0002-0337-9293","position":5,"is_corresponding":false},{"id":670771,"name":"Norman D. Hogikyan","orcid":"0000-0003-1783-4338","position":6,"is_corresponding":false},{"id":376563,"name":"Matthew E. Spector","orcid":"0000-0001-7646-6075","position":7,"is_corresponding":false},{"id":376560,"name":"Andrew G. Shuman","orcid":"0000-0002-9305-7860","position":8,"is_corresponding":false},{"id":383060,"name":"Chaz L. Stucken","orcid":"0000-0003-1448-3376","position":9,"is_corresponding":false},{"id":304744,"name":"Steven B. Chinn","orcid":"0000-0003-4282-0640","position":10,"is_corresponding":false},{"id":1499272,"name":"Douglas C. Chepeha","orcid":null,"position":11,"is_corresponding":false},{"id":274519,"name":"Shruti Jolly","orcid":"0000-0002-8174-5199","position":12,"is_corresponding":false},{"id":249357,"name":"Michelle Mierzwa","orcid":"0000-0002-3923-9970","position":13,"is_corresponding":false},{"id":70262,"name":"Carol R. Bradford","orcid":"0000-0002-2768-4532","position":14,"is_corresponding":false},{"id":383065,"name":"Avraham Eisbruch","orcid":"0000-0002-4102-5197","position":15,"is_corresponding":false},{"id":13324,"name":"Thomas E. Carey","orcid":"0000-0002-5202-7518","position":16,"is_corresponding":false},{"id":70265,"name":"Mark E. Prince","orcid":"0000-0002-1120-9008","position":17,"is_corresponding":false},{"id":70267,"name":"Gregory T. Wolf","orcid":"0000-0002-3219-9515","position":18,"is_corresponding":false},{"id":383061,"name":"Francis P. Worden","orcid":"0000-0002-6632-4951","position":19,"is_corresponding":false},{"id":737897,"name":"Zachary Risch","orcid":null,"position":0,"is_corresponding":true}],"reference_count":17,"raw_metadata":null,"created_at":"2026-07-19T02:59:20.067334Z","pmid":"41403153","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}