{"doi":"10.1002/hed.28182","title":"Postdiagnosis Smoking Cessation and Survival Outcomes of Head and Neck Cancer Patients","abstract":"BACKGROUND: Post-diagnosis smoking remains prevalent among head and neck squamous cell carcinoma (HNSCC) patients. Smoking cessation may improve patient outcomes. METHODS: A prospective longitudinal cohort study (2008-2014) included 835 newly diagnosed HNSCC patients and followed up for 7 years. Participants were categorized by smoking behavior (never smokers, former smokers, quitters, continuing smokers, and intermittent smokers). The primary outcomes were overall survival (OS) and recurrence-free survival (RFS). RESULTS: Smoking cessation after diagnosis was associated with significantly improved OS. Quitters had a 61% reduction in mortality risk compared to continuing smokers (HR: 0.39, 95% CI: 0.22, 0.69), with the greatest benefit in oral cavity cancer patients (HR: 0.28, 95% CI: 0.12, 0.65). Intermittent smokers also showed improved survival (HR: 0.50, 95% CI: 0.31, 0.79). RFS did not significantly differ based on smoking behavior. CONCLUSIONS: Smoking cessation post-diagnosis improves OS, particularly in oral cavity cancer patients, highlighting the importance of targeted smoking cessation interventions in HNSCC care.","journal":"Head & Neck","year":2025,"id":514277,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9211,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1377483,"name":"Garret Guthrie","orcid":null,"position":1,"is_corresponding":false},{"id":1187435,"name":"Siddhi Patil","orcid":null,"position":2,"is_corresponding":false},{"id":1056217,"name":"William J. Benjamin","orcid":"0000-0003-4116-7408","position":3,"is_corresponding":false},{"id":348701,"name":"Ming Tan","orcid":"0000-0003-2533-8246","position":4,"is_corresponding":false},{"id":1376862,"name":"Jonathan P. Giurintano","orcid":"0000-0002-0803-6732","position":5,"is_corresponding":false},{"id":1120647,"name":"Matthew E. Witek","orcid":"0000-0003-0570-3293","position":6,"is_corresponding":false},{"id":1376746,"name":"Peter H. Ahn","orcid":null,"position":7,"is_corresponding":false},{"id":292843,"name":"Kathryn L. Taylor","orcid":"0000-0001-7351-0413","position":8,"is_corresponding":false},{"id":70267,"name":"Gregory T. Wolf","orcid":"0000-0002-3219-9515","position":9,"is_corresponding":false},{"id":433961,"name":"Ruzong Fan","orcid":"0000-0002-7603-2135","position":10,"is_corresponding":false},{"id":70266,"name":"Laura S. Rozek","orcid":"0000-0001-6731-7000","position":11,"is_corresponding":false},{"id":1376150,"name":"Elham Mohebbi","orcid":"0000-0003-0868-4067","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:48:29.165853Z","pmid":"40370118","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}