{"doi":"10.1002/hed.28180","title":"Artificial Intelligence Measured Tumor Burden and Pre‐Treatment Circulating Tumor <scp>DNA</scp> in Human Papilloma Virus‐Associated Oropharynx Cancer","abstract":"BACKGROUND: Artificial intelligence (AI)-based imaging analysis and circulating tumor-associated DNA (ctDNA) are both being used diagnostically in HPV-driven oropharynx squamous cell carcinoma (HPV-OPSCC). We evaluated associations between AI-measured tumor burden and ctDNA. METHODS: We analyzed 170 patients treated definitively for HPV-OPSCC. All had pre-treatment serum tumor-tissue modified viral (TTMV) ctDNA levels. An AI algorithm measured tumor and lymph nodes on CT scans. Linear regressions detected associations between ctDNA (fragments/mL) and automated volumes, clinical tumor (T) and nodal (N) stage, and disease factors. RESULTS: Automated tumor volume (coeff = 39.43, p < 0.001), nodal volume (coeff = 39.54, p < 0.001), T stage (coeff = 1031.09, p = 0.009), and N stage (coeff = 1840, p = 0.018) were associated with ctDNA. On multivariable analysis, tumor (coeff = 34.79, p = 0.001) and nodal volumes (coeff = 24.68, p = 0.022) were associated with ctDNA; T and N stage were not. CONCLUSIONS: Automated volumetrics are independently and more strongly associated with ctDNA, compared with clinical stage. Automated volumetrics provide a practical correlate to ctDNA.","journal":"Head & Neck","year":2025,"id":523273,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9453,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":351629,"name":"Zezhong Ye","orcid":"0000-0003-0369-7432","position":1,"is_corresponding":false},{"id":16764,"name":"Jonathan D. Schoenfeld","orcid":"0000-0002-5119-0401","position":2,"is_corresponding":false},{"id":1395705,"name":"Homan Mohammadi","orcid":"0000-0001-7471-643X","position":3,"is_corresponding":false},{"id":274930,"name":"Jeffrey P. Guenette","orcid":"0000-0002-4684-5469","position":4,"is_corresponding":false},{"id":1071899,"name":"Eleni M. Rettig","orcid":"0000-0002-4715-0087","position":5,"is_corresponding":false},{"id":231279,"name":"Glenn J. Hanna","orcid":"0000-0002-9969-2523","position":6,"is_corresponding":false},{"id":229101,"name":"Benjamin H. Kann","orcid":"0000-0002-4313-2754","position":7,"is_corresponding":false},{"id":1395704,"name":"Mina Bakhtiar","orcid":"0000-0001-5321-3913","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T02:50:03.004175Z","pmid":"40322795","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}