{"doi":"10.1002/hed.28167","title":"Surgical Versus Non‐Surgical Treatment of Advanced Oropharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis","abstract":"BACKGROUND: This review aims to compare survival outcomes of surgical versus non-surgical treatment of advanced-stage OPSCC. METHODS: CINAHL, Cochrane Library, PubMed, and Scopus were searched. Studies comparing the survival of patients with advanced OPSCC treated surgically (±adjuvant therapy) or non-surgically were included. Meta-analyses hazard ratio (HR) and proportions (%) were performed for the outcomes of 2-, 3-, and 5-year overall (OS), disease-free (DFS), disease-specific (DSS), and relapse-free (RFS) survival. RESULTS: Forty-four studies reporting on (N = 35 681) patients were included, with a mean age of 58.9. For advanced-stage disease, primary treatment with surgery and chemoradiotherapy (CRT) demonstrated the best 5-year OS, at 67.1% (95% CI 55.6-77.6). Survival outcomes favored Surgery + CRT over other primary treatment modalities. CONCLUSIONS: Surgical treatment with adjuvant CRT may be associated with better OS outcomes compared with non-surgical treatment. Further research is needed to determine superior treatment modalities in OPSCC subgroups, such as HPV+ tumors.","journal":"Head & Neck","year":2025,"id":530651,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9498,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1410615,"name":"Johnny M. Owen","orcid":null,"position":1,"is_corresponding":false},{"id":1153877,"name":"Shaun A. Nguyen","orcid":"0000-0003-0664-4571","position":2,"is_corresponding":false},{"id":1153847,"name":"Alexandra E. Kejner","orcid":"0000-0002-1999-2818","position":3,"is_corresponding":false},{"id":363238,"name":"Jason G. Newman","orcid":"0000-0002-4700-360X","position":4,"is_corresponding":false},{"id":1271246,"name":"Emily Brennan","orcid":"0000-0001-8463-1499","position":5,"is_corresponding":false},{"id":1410289,"name":"William G. Albergotti","orcid":"0000-0003-1747-6593","position":6,"is_corresponding":false},{"id":1410288,"name":"Megan K. Scharner","orcid":"0009-0000-8111-1885","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T02:51:05.836974Z","pmid":"40251951","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}