{"doi":"10.1002/hed.28062","title":"Exploring Quantitative <scp>MRI</scp> Biomarkers of Head and Neck Post‐Radiation Lymphedema and Fibrosis: Post Hoc Analysis of a Prospective Trial","abstract":"BACKGROUND: Quantifying head and neck lymphedema and fibrosis (HN-LEF) is crucial in the investigation and management of treatment sequelae in head and neck cancer (HNC). METHODS: The T1- and T2-weighted MRI signal intensity (SI) was examined in relation to HN-LEF categories per physical/tactile examination (No-LEF, A-B = edema, C = edema + fibrosis, D = fibrosis), and MRI structural volumes were examined in relation to a novel 10-point HN-LEF score in the intraoral and submental regions. RESULTS: We identified differences in ranks among HN-LEF categories in relation to the MRI SI (A-B and C are higher than D and No-LEF for T2 SI, and A-B is the highest for T1). Furthermore, six pairs of FOM volumes on MRI demonstrated a strong negative correlation (p < 0.05) with the HN-LEF score at adjacent palpable sites. CONCLUSION: Both MRI SI and structural volumes can potentially be imaging biomarkers of edematous soft tissue states in HNC patients.","journal":"Head & Neck","year":2025,"id":529852,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":724570,"name":"Shitong Mao","orcid":"0000-0002-5122-7497","position":1,"is_corresponding":false},{"id":371590,"name":"Jihong Wang","orcid":"0000-0003-0073-7443","position":2,"is_corresponding":false},{"id":709121,"name":"Holly McMillan","orcid":"0000-0001-6875-7497","position":3,"is_corresponding":false},{"id":351182,"name":"Abdallah Mohamed","orcid":"0000-0003-2064-7613","position":4,"is_corresponding":false},{"id":709606,"name":"Sheila Buoy","orcid":null,"position":5,"is_corresponding":false},{"id":266114,"name":"Sara Ahmed","orcid":"0000-0002-1791-8366","position":6,"is_corresponding":false},{"id":689224,"name":"Samuel L. Mulder","orcid":"0000-0001-5185-4805","position":7,"is_corresponding":false},{"id":653657,"name":"Mohamed A. Naser","orcid":"0000-0003-1020-4966","position":8,"is_corresponding":false},{"id":426705,"name":"Renjie He","orcid":"0000-0001-9166-6286","position":9,"is_corresponding":false},{"id":519105,"name":"Kareem A. Wahid","orcid":"0000-0002-0503-0175","position":10,"is_corresponding":false},{"id":1409660,"name":"Melissa Mei Chen","orcid":null,"position":11,"is_corresponding":false},{"id":345632,"name":"Yao Ding","orcid":"0000-0002-0559-5846","position":12,"is_corresponding":false},{"id":346829,"name":"Amy C. Moreno","orcid":"0000-0001-6762-6807","position":13,"is_corresponding":false},{"id":351185,"name":"Stephen Y. Lai","orcid":"0000-0001-8301-7286","position":14,"is_corresponding":false},{"id":295555,"name":"Clifton D. Fuller","orcid":"0000-0002-5264-3994","position":15,"is_corresponding":false},{"id":447333,"name":"Katherine A. Hutcheson","orcid":"0000-0003-3710-5706","position":16,"is_corresponding":false},{"id":1283605,"name":"MD Anderson Head and Neck Cancer Symptom Working Group","orcid":null,"position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-19T02:51:01.235017Z","pmid":"39794912","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}